Introduction：Basic information about CAS 493-48-1|(S)-Salsolidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-Salsolidine |
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| CAS Number | 493-48-1 | Molecular Weight | 207.27 |
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| Density | 1.034g/cm3 | Boiling Point | 313.4ºC at 760mmHg |
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| Molecular Formula | C12H17NO2 | Melting Point | / |
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| MSDS | / | Flash Point | 127.1ºC |
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Names
| Name | salsolidine |
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| Synonym | More Synonyms |
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(S)-Salsolidine BiologicalActivity
| Description | (S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (Ki=63 μM). The R enantiomer of Salsolidine is more potent than the S form (Ki=26 μM)[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
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| Target | Human Endogenous Metabolite |
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| In Vitro | Salsolidine is a dopamine-derived tetrahydroisoquinoline-alkaloid which possesses an asymmetric center at C-1 and exists as R and S enantiomers[1]. |
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| References | [1]. Dostert P, et al. Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases. J Neural Transm. 1988;74(2):61-74. |
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Chemical & Physical Properties
| Density | 1.034g/cm3 |
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| Boiling Point | 313.4ºC at 760mmHg |
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| Molecular Formula | C12H17NO2 |
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| Molecular Weight | 207.27 |
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| Flash Point | 127.1ºC |
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| Exact Mass | 207.12600 |
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| PSA | 30.49000 |
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| LogP | 2.23930 |
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| Vapour Pressure | 0.000496mmHg at 25°C |
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| Index of Refraction | 1.509 |
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| InChIKey | HMYJLVDKPJHJCF-QMMMGPOBSA-N |
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| SMILES | COc1cc2c(cc1OC)C(C)NCC2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NX5018500
- CHEMICAL NAME :
- Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-
- CAS REGISTRY NUMBER :
- 493-48-1
- LAST UPDATED :
- 199312
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C12-H17-N-O2
- MOLECULAR WEIGHT :
- 207.30
- WISWESSER LINE NOTATION :
- T66 CMT&J B1 HO1 IO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 41,249,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 15(2),54,1981
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Synonyms
| rac-salsolidine |
| 6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE |
| 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline |
| 1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline |
