CAS 22316-55-8|N-Desmethyl Clobazam
| Common Name | N-Desmethyl Clobazam | ||
|---|---|---|---|
| CAS Number | 22316-55-8 | Molecular Weight | 286.71300 |
| Density | 1.363 g/cm3 | Boiling Point | 601.8ºC at 760 mmHg |
| Molecular Formula | C15H11ClN2O2 | Melting Point | / |
| MSDS | / | Flash Point | 317.7ºC |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | N-Desmethyl Clobazam |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.363 g/cm3 |
|---|---|
| Boiling Point | 601.8ºC at 760 mmHg |
| Molecular Formula | C15H11ClN2O2 |
| Molecular Weight | 286.71300 |
| Flash Point | 317.7ºC |
| Exact Mass | 286.05100 |
| PSA | 52.90000 |
| LogP | 3.49700 |
| Vapour Pressure | 1.95E-14mmHg at 25°C |
| Index of Refraction | 1.631 |
| InChIKey | RRTVVRIFVKKTJK-UHFFFAOYSA-N |
| SMILES | O=C1CC(=O)N(c2ccccc2)c2cc(Cl)ccc2N1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2583 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3760074
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302 + H312 + H332-H319 |
| Precautionary Statements | P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235 |
| RIDADR | UN 1648 3 / PGII |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles25
More Articles| Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate. Leg. Med. (Tokyo.) 12(6) , 300-4, (2010) Clobazam is a benzodiazepine with anti-anxiety and anticonvulsant properties marketed in several countries. Norclobazam, a metabolite of clobazam, has similar pharmacological activity but weaker sedat... | |
| Simultaneous determination of clobazam and its major metabolite in human plasma by a rapid HPLC method. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 823(2) , 167-71, (2005) A rapid and specific HPLC method has been developed and validated for simultaneous determination of clobazam, the anticonvulsant agent, and its major metabolite in human plasma. The sample preparation... | |
| A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam. Brain Dev. 26(8) , 530-4, (2004) N-desmethylclobazam (N-CLB), the major metabolite of clobazam (CLB), exerts a large influence on therapeutic and adverse effects of CLB. A substantial inter-individual variability has been observed in... |
Synonyms
| N-Desmethylclobazam |
| 7-Chloro-5-phenyl-1,5-dihydro-3H-1,5-benzodiazepine-2,4-dione N-Desmethylclobazam |
| 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione |
| Clobazam impurity A |
