CAS 1898-66-4|DPPH
Introduction：Basic information about CAS 1898-66-4|DPPH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DPPH | ||
|---|---|---|---|
| CAS Number | 1898-66-4 | Molecular Weight | 394.318 |
| Density | / | Boiling Point | / |
| Molecular Formula | C18H12N5O6 | Melting Point | 136-138ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | 1,1-diphenyl-2-picrylhydrazyl |
|---|---|
| Synonym | More Synonyms |
DPPH BiologicalActivity
| Description | DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | DPPH shows a strong absorption band at 517 nm due to its odd electron and solution appears a deep violet colour, the absorption vanishes as the electron pairs off. The resulting decolorization is stoichiometric with respect to the number of electrons taken up. The alcoholic solutions of 0.5 mM are densely colored and at this concentration, the Lambert-Beer law is obeyed over the useful range of absorption[1]. DPPH assay is a rapid, simple, inexpensive and widely used method to measure the ability of compounds to act as free radical scavengers or hydrogen donors, and to evaluate antioxidant activity of foods. It can also be used to quantify antioxidants in complex biological systems, for solid or liquid samples. This method is easy and applies to measure the overall antioxidant capacity and the free radical scavenging activity of fruit and vegetable juice. This assay has been successfully utilized for investigating antioxidant properties of wheat grain and bran, vegetables, conjugated linoleic acids, herbs, edible seed oils, and flours in several different solvent systems including ethanol, aqueous acetone, methanol, aqueous alcohol and benzene. It is a convenient method for the antioxidant assay of cysteine, glutathione, ascorbic acid, tocopherol and polyhydroxy aromatic compounds, for olive oil, fruits, juices and wines[1]. |
| References | [1]. Kedare SB, et al. Genesis and development of DPPH method of antioxidant assay. J Food Sci Technol. 2011 Aug;48(4):412-22. |
Chemical & Physical Properties
| Melting Point | 136-138ºC |
|---|---|
| Molecular Formula | C18H12N5O6 |
| Molecular Weight | 394.318 |
| Exact Mass | 394.078766 |
| PSA | 140.70000 |
| LogP | 5.97000 |
| Appearance of Characters | green |
| Storage condition | 2-8°C |
| Water Solubility | Soluble in dimethyl formamide, ethanol, chloroform, ether, carbon disulfinde, acetone, oils, carbon tetrachloride, glacial acetic acid and toluene. Insoluble in water. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06207
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H334 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S24/25 |
| RIDADR | UN2811 |
| WGK Germany | 1 |
| RTECS | MW3250000 |
| Packaging Group | II |
| Hazard Class | 6.1 |
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Synonyms
| DPPH radical |
| diphenylpicrylhydrazylfreeradical |
| 2,2-Diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl |
| DPPH |
| di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium |
| 1,1-Diphenyl-2-picrylhydrazyl Free Radical |
| 2,2-Diphenyl-1-(2,4,6-trinitrophenyl)hydrazino |
| Hydrazinyl, 2,2-diphenyl-1-(2,4,6-trinitrophenyl)- |
| Diphenylpicrylhydrazyl. |
| 1,1-Diphenyl-2-picrylhydrazyl radical |
| 2,2-Diphenylpicrylhydrazyl |
| 2,2-diphenyl-1-picrylhydrazyl |
| 1-diphenyl-2-picrylhydrazyl |
| EINECS 217-591-8 |
| Diphenypicrylhydrazyl |
| MFCD00007231 |
