Introduction：Basic information about CAS 78842-13-4|2′-Deoxy-2′-fluoroguanosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2′-Deoxy-2′-fluoroguanosine |
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| CAS Number | 78842-13-4 | Molecular Weight | 285.232 |
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| Density | 2.2±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C10H12FN5O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one |
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| Synonym | More Synonyms |
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2′-Deoxy-2′-fluoroguanosine BiologicalActivity
| Description | 2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of <0.35 μM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection |
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| Target | EC90: <0.35 μM (influenza virus A and B)[1] |
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| References | [1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8. [2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7. |
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Chemical & Physical Properties
| Density | 2.2±0.1 g/cm3 |
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| Molecular Formula | C10H12FN5O4 |
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| Molecular Weight | 285.232 |
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| Exact Mass | 285.087341 |
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| PSA | 140.27000 |
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| LogP | -0.53 |
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| Appearance of Characters | Powder | White to Off-white |
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| Index of Refraction | 1.876 |
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Safety Information
| Hazard Codes | Xn |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2'-fluorodeoxyguanisine |
| 2'-Fluoro-2'-deoxyguanosine |
| 2'-fluorodeoxyguanosine |
| 2'-fluoro guanosine |
| 2'-fluoro-2',3'-dideoxyguanosine |
| 2'-Dfgs |
| 2'-Deoxy-2'-fluoroguanosine |
| Guanosine,2'-deoxy-2'-fluoro |
| Guanosine, 2'-deoxy-2'-fluoro- |
