Introduction：Basic information about CAS 77-94-1|Tributyl citrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Tributyl citrate is a citric acid ester. Tributyl citrate can be used as an excipient, such as plasticizer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
Research Areas >>OthersSignaling Pathways >>Others >>Others
References
[1]. FINKELSTEIN M, et al. Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate. Toxicol Appl Pharmacol. 1959 May;1(3):283-98.
[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.
Behavioral - somnolence (general depressed activity) Vascular - other changes
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8120 mg/kg/14D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964
Safety Information
Personal Protective Equipment
Eyeshields;Gloves
Hazard Codes
T: Toxic;
Risk Phrases
R25
Safety Phrases
S26-S36/37/39-S45-S24/25
RIDADR
UN 2811 6.1/PG 2
WGK Germany
3
RTECS
TZ8608000
HS Code
2918150000
Customs
HS Code
2918150000
Summary
2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%
Articles10
More Articles
Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin.
Eur. J. Pharm. Biopharm. 91 , 9-15, (2015)
Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Thei...
Improved mechanical property and water resistance of zein films by plasticization with tributyl citrate.
J. Agric. Food Chem. 60(23) , 5988-93, (2012)
Pure zein film is intrinsically rigid and brittle and lacks necessary mechanical properties for industrial processing. In addition, pure zein film is sensitive to high relative humidity, which limits ...
Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion.
Eur. J. Pharm. Biopharm. 79(3) , 635-45, (2011)
The objective of this study was the development of retarded release pellets using vegetable calcium stearate (CaSt) as a thermoplastic excipient. The matrix carrier was hot melt extruded and pelletize...
