CAS 34123-59-6|Isoproturon

Introduction：Basic information about CAS 34123-59-6|Isoproturon, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Isoproturon BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles37
8. Synonyms

Common Name	Isoproturon
CAS Number	34123-59-6	Molecular Weight	206.284
Density	1.1±0.1 g/cm3	Boiling Point	353.2±25.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₈N₂O	Melting Point	155-156ºC
MSDS	ChineseUSA	Flash Point	167.4±23.2 °C
Symbol	GHS07, GHS08, GHS09	Signal Word	Warning

Names

Name	isoproturon
Synonym	More Synonyms

Isoproturon BiologicalActivity

Description	Isoproturon belongs to the phenylurea herbicide family and is a systemic and selective herbicide. Isoproturon is widely applied for killing weeds in farmland, which can be used in the control of annual grasses and broad-leaved weeds in spring and winter wheat, winter rye and spring and winter barley[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Feng Fan Lu, et al. Isoproturon-Induced Salicylic Acid Confers Arabidopsis Resistance to Isoproturon Phytotoxicity and Degradation in Plants. J Agric Food Chem. 2018 Dec 19;66(50):13073-13083. [2]. Mian Muhammad, et al. Determination of Isoproturon in Environmental Samples Using the QuEChERS Extraction-Spectrofluorimetric Method. Environ Toxicol Chem. 2019 Dec;38(12):2614-2620.

Description

Isoproturon belongs to the phenylurea herbicide family and is a systemic and selective herbicide. Isoproturon is widely applied for killing weeds in farmland, which can be used in the control of annual grasses and broad-leaved weeds in spring and winter wheat, winter rye and spring and winter barley[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Feng Fan Lu, et al. Isoproturon-Induced Salicylic Acid Confers Arabidopsis Resistance to Isoproturon Phytotoxicity and Degradation in Plants. J Agric Food Chem. 2018 Dec 19;66(50):13073-13083.

[2]. Mian Muhammad, et al. Determination of Isoproturon in Environmental Samples Using the QuEChERS Extraction-Spectrofluorimetric Method. Environ Toxicol Chem. 2019 Dec;38(12):2614-2620.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	353.2±25.0 °C at 760 mmHg
Melting Point	155-156ºC
Molecular Formula	C₁₂H₁₈N₂O
Molecular Weight	206.284
Flash Point	167.4±23.2 °C
Exact Mass	206.141907
PSA	32.34000
LogP	2.32
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.555
InChIKey	PUIYMUZLKQOUOZ-UHFFFAOYSA-N
SMILES	CC(C)c1ccc(NC(=O)N(C)C)cc1
Storage condition	APPROX 4°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT0170000

CHEMICAL NAME :: Urea, 1,1-dimethyl-3-(p-isopropylphenyl)-

CAS REGISTRY NUMBER :: 34123-59-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C12-H18-N2-O

MOLECULAR WEIGHT :: 206.32

WISWESSER LINE NOTATION :: 1Y1&R DMVN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1826 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >670 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1043 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 3042 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 gm/kg/10W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 gm/kg/3W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg/5D (Intermittent)

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 28,862,1990

Safety Information

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H332-H351-H410
Precautionary Statements	P273-P281-P501
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R40;R50/53
Safety Phrases	S36/37-S60-S61-S26
RIDADR	UN 3077
RTECS	YT0170000
Packaging Group	III
HS Code	2924299039

Customs

HS Code	2924299039
Summary	2924299039. VAT:17.0%. Tax rebate rate:9.0%. Supervision conditions:S(import or export registration certificate for pesticides). MFN tariff:6.5%. General tariff:30.0%

Articles37

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Simultaneous extraction and determination of various pesticides in environmental waters.

J. Sep. Sci. 37(24) , 3699-705, (2014)

A simple and rapid method was developed for the simultaneous analysis of nine different pesticides in water samples by gas chromatography with mass spectrometry. A number of parameters that may affect...

Multiresidue method for the determination of 13 pesticides in three environmental matrices: water, sediments and fish muscle.

Talanta 85(3) , 1500-7, (2011)

Pesticides residues in aquatic ecosystems are an environmental concern which requires efficient analytical methods. In this study, we proposed a generic method for the quantification of 13 pesticides ...

Synonyms

N,N-Dimethyl-N'-(4-(1-methylethyl)phenyl)urea

N,N-Dimethyl-N'-[4-(1-methylethyl)phenyl]urea

Protugan

N,N-dimethyl-N’-[4-(1-methylethyl)phenyl]urea

Tolkan

1,1-dimethyl-3-[4-(propan-2-yl)phenyl]urea

I.P.U.

Isoproturon

Graminon

Urea, N,N-dimethyl-N'-[4-(1-methylethyl)phenyl]-

Nocilon

EINECS 251-835-4

MFCD00078684

3-(4-Isopropylphenyl)-1,1-dimethylurea

3-p-Cumenyl-1,1-dimethylurea

Alon

Arelon

Belgran

1,1-dimethyl-3-(4-propan-2-ylphenyl)urea

Zodiac TX

N-(4-Isopropylphenyl)-N',N'-dimethylurea

Arelon R

N,N-dimethyl-N’-[4-(propan-2-yl)phenyl]urea

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