CAS 88373-72-2|(D-Pen2,Pen5)-Enkephalin

Introduction：Basic information about CAS 88373-72-2|(D-Pen2,Pen5)-Enkephalin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name(D-Pen2,Pen5)-Enkephalin
CAS Number88373-72-2Molecular Weight645.790
Density1.4±0.1 g/cm3Boiling Point1038.6±65.0 °C at 760 mmHg
Molecular FormulaC30H39N5O7S2Melting Point/
MSDS/Flash Point581.9±34.3 °C

Names

Name(4R,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
SynonymMore Synonyms

(D-Pen2,Pen5)-Enkephalin BiologicalActivity

Description[DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin (HY-P0288)[1].
Related CatalogSignaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease
Target

δ Opioid Receptor/DOR

In Vivo[DPen2, Pen5] Enkephalin (0-3.32 μg/kg, IP) impairs acquisition of an automated jump-up avoidance response in rats and acquisition of a one-way active avoidance response in mice[1]. Animal Model: Male Sprague-Dawley rats (260-280 g)[1] Dosage: 0, 1.16, 11.6 μg/kg Administration: IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding. Result: Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect. Animal Model: Male Sprague-Dawley rats (260-280 g)[1] Dosage: 0, 0.332, 3.32 μg/kg Administration: IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment Result: Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect.

Chemical & Physical Properties

Density1.4±0.1 g/cm3
Boiling Point1038.6±65.0 °C at 760 mmHg
Molecular FormulaC30H39N5O7S2
Molecular Weight645.790
Flash Point581.9±34.3 °C
Exact Mass645.229065
PSA250.55000
LogP2.24
Vapour Pressure0.0±0.3 mmHg at 25°C
Index of Refraction1.653
InChIKeyMCMMCRYPQBNCPH-HIGZBPRKSA-N
SMILESCC1(C)SSC(C)(C)C(NC(=O)C(N)Cc2ccc(O)cc2)C(=O)NCC(=O)NC(Cc2ccccc2)C(=O)NC1C(=O)O

Safety Information

WGK Germany3

Synonyms

[D-Pen2,Pen5]-Enkephalin
1,2-Dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid, 13-[[(2S)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-3,3,14,14-tetramethyl-6,9,12-trioxo-7-(phenylmethyl)-, (4S,7S,13S)-
(4S,7S,13S)-7-Benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-13-(L-tyrosylamino)-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
DPDPE
CAS 122507-47-5|(D-Pen2,p-chloro-Phe4,D-Pen5)-Enkephalin
CAS 129133-27-3|(D-Phe12,Nle21.38)-CRF (12-41) (human, rat) trifluoroacetate salt
Recommended......
CAS 887590-18-3|3-(4-CHLORO-BE CAS 881219-73-4|1,2,3-Trimethy CAS 882757-24-6|N,N'-[[5-[ CAS 884507-35-1|N-Methyl-4-[5- CAS 884497-38-5|2-(2-Methoxyph CAS 884497-34-1|4-Ethyl-5-meth CAS 886361-30-4|Methyl 2-amino CAS 885950-52-7|2-(4-BROMOPHEN CAS 885675-66-1|4-(2-CHLORO-6- CAS 886444-10-6|METHYL 4-(4-(3 CAS 887625-72-1|2-BROMO-4-(3-( CAS 887589-43-7|6-Bromo-4-chlo CAS 881672-80-6|1-(5,6-Dimethy CAS 882188-87-6|TERT-BUTYL 3-( CAS 884049-52-9|SPIRO[PIPERIDI CAS 885518-74-1|4-Iodo-1H-inda CAS 885519-90-4|4-Formyl-1H-in CAS 885521-76-6|4-Bromo-1H-ind CAS 88805-68-9|3-AMINO-1H-INDA CAS 889451-31-4|1-(1H-Pyrazolo
Disclaimer

This site is a non-commercial website, not accept any sponsorship and advertising. The content is collated from the Internet, does not represent the position of this site, for personal reference only, please distinguish by yourself! The belongs to the original author.

Copyright © 2025 All Rights Reserved.

TOP