Introduction：Basic information about CAS 34368-04-2|dobutamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | dobutamine |
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| CAS Number | 34368-04-2 | Molecular Weight | 301.38000 |
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| Density | 1.189g/cm3 | Boiling Point | 527.7ºC at 760mmHg |
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| Molecular Formula | C18H23NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 169.8ºC |
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Names
| Name | dobutamine |
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| Synonym | More Synonyms |
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dobutamine BiologicalActivity
| Description | Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| In Vivo | Dobutamine has a rapid onset of action and a short half-life [2]. Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3]. Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3]. Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice[3]. Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3]. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4]. Animal Model: Tgαq*44 mice (heart failure models)[3] Dosage: 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose Administration: Intraperitoneal injection Result: Induced different response in cardiac function on a low and high dose in mice with with heart failure. |
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| References | [1]. Tuttle RR, et al. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circ Res. 1975 Jan;36(1):185-96. [2]. Vallet B, et al. Dobutamine: mechanisms of action and use in acute cardiovascular pathology. Ann Cardiol Angeiol (Paris). 1991 Jun;40(6):397-402. [3]. Tyrankiewicz U , et al. Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging. 2013 Mar;37(3):669-77. [4]. Tibayan FA, et al. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):438-44. |
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Chemical & Physical Properties
| Density | 1.189g/cm3 |
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| Boiling Point | 527.7ºC at 760mmHg |
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| Molecular Formula | C18H23NO3 |
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| Molecular Weight | 301.38000 |
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| Flash Point | 169.8ºC |
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| Exact Mass | 301.16800 |
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| PSA | 72.72000 |
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| LogP | 3.34770 |
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| InChIKey | JRWZLRBJNMZMFE-UHFFFAOYSA-N |
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| SMILES | CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1 |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | 20/21/22-63 |
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| Safety Phrases | 22-26-36/37/39 |
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| WGK Germany | 3 |
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| HS Code | 2922509090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol |
| DOBUTAMINE HCL |
| 1,2-Benzenediol,4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-,(+-) |
| (+/-)-dobutamine |
| DOBUTAMINE HYDROCHLORIDE |
| 4-[2-[4-(4-HYDROXYPHENYL)BUTAN-2-YLAMINO]ETHYL]BENZENE-1,2-DIOL |
