CAS 2203-97-6|Hydrocortisone hemisuccinate
| Common Name | Hydrocortisone hemisuccinate | ||
|---|---|---|---|
| CAS Number | 2203-97-6 | Molecular Weight | 462.533 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 685.5±55.0 °C at 760 mmHg |
| Molecular Formula | C25H34O8 | Melting Point | / |
| MSDS | USA | Flash Point | 231.1±25.0 °C |
Names
| Name | Hydrocortisone 21-hemisuccinate |
|---|---|
| Synonym | More Synonyms |
Hydrocortisone hemisuccinate BiologicalActivity
| Description | Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inflammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC)[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Glucocorticoid Receptor |
| Target | IL-6:6.7 μM (IC50) IL-3:21.4 μM (IC50) |
| In Vitro | Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3]. Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3]. |
| In Vivo | Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2]. Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2] Dosage: 30 mg/kg Administration: P.o. twice daily for 5 days Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight. |
| References | [1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. [2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53. [3]. Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9(4):469-73. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 685.5±55.0 °C at 760 mmHg |
| Molecular Formula | C25H34O8 |
| Molecular Weight | 462.533 |
| Flash Point | 231.1±25.0 °C |
| Exact Mass | 462.225372 |
| PSA | 138.20000 |
| LogP | 2.13 |
| Vapour Pressure | 0.0±4.8 mmHg at 25°C |
| Index of Refraction | 1.587 |
| InChIKey | VWQWXZAWFPZJDA-CGVGKPPMSA-N |
| SMILES | CC12CCC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)COC(=O)CCC(=O)O |
| Storage condition | −20°C |
| Water Solubility | Practically insoluble in water, freely soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali carbonates and alkali hydroxides. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4200 mg/kg/10W-C
- TOXIC EFFECTS :
- Immunological Including Allergic - decrease in humoral immune response
- REFERENCE :
- BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 41,523,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4704 No. of Facilities: 114 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16945 (estimated) No. of Female Employees: 15681 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TU5010147 |
Articles29
More Articles| Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals. Am. J. Vet. Res. 73(1) , 68-75, (2012) To compare daily endogenous cortisol production rate and the pharmacokinetics of an i.v. bolus of hydrocortisone between neonatal foals and adult horses.10 healthy full-term 2- to 4-day-old foals and ... | |
| The compatibility of a low concentration of hydrocortisone sodium succinate with selected drugs during a simulated Y-site administration. Crit. Care Resusc. 15(1) , 63-6, (2013) Bolus dose concentrations of hydrocortisone (50mg/mL) are reported to be incompatible with midazolam and ciprofloxacin in Y-site mixing studies. We evaluated the physical and chemical compatibility of... | |
| Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats. Steroids 75(12) , 853-8, (2010) Accumulating evidence suggests that adiponectin plays an important role in the genesis of obesity and insulin resistance. Although it has been shown that glucocortocoids (GC) inhibit adiponectin expre... |
Synonyms
| Hydrocortisone 21-he |
| MFCD00046256 |
| saxizon |
| cortisol,hydrogensuccinate |
| cortisolsuccinate |
| Butanedioic acid, mono(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl) ester |
| hydrocortisone hemisuccinate ester |
| 4-{[(11α)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoic acid |
| CORTISOL HEMISUCCINATE |
| Hydrocortisone hydrogen succinate |
| 4-[(11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoic acid |
| Hydrocortisone hemisuccinate |
| EINECS 218-612-3 |
| CORTISOL 21-HEMISUCCINATE |
| hydrocortisone-21-O-hemisuccinate |
| Hydrocortizone Succinate |
| Butanedioic acid, mono[(11α)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester |
| hydrocortisone21-hemisuccinate*freeacid |
| HYDROCORTISONE SUCCINATE |
