Introduction：Basic information about CAS 18486-69-6|(−)-Myrtenal, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats[1][2].
Related Catalog
Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
In Vitro
(−)-Myrtenal ((1R)-(−)-Myrtenal; 0.1-5 mM; for 24 h) exerts strong cytotoxic effect (IC50 = 5.3 mM) on human colon tumour (HT29) and human normal colon epithelial cells (CCD 841 CoTr)[1].
In Vivo
(−)-Myrtenal ((1R)-(−)-Myrtenal; orally; 80 mg/kg/day for 28 days) reveals decreased the levels of plasma glucose, improved the plasma insulin levels, up-regulation of IRS2, Akt and GLUT2 in liver and IRS2, Akt and GLUT4 protein expression in skeletal muscle in diabetic rats induced by single intraperitoneal injection of Streptozotocin (STZ) (40 mg/kg bw)[2].
References
[1]. Mariusz Trytek, et al. Biological activity of oxygenated pinene derivatives on human colon normal and carcinoma cells. Flavour and Fragrance Journal, Volume33, Issue6, November 2018.
[2]. Ayyasamy Rathinam, et al. Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. Chem Biol Interact. 2016 Aug 25;256:161-6.
Chemical & Physical Properties
Density
0.988 g/mL at 20ºC(lit.)
Boiling Point
220-221ºC(lit.)
Molecular Formula
C10H14O
Molecular Weight
150.22
Flash Point
174 °F
Exact Mass
150.10400
PSA
17.07000
LogP
2.17770
Appearance of Characters
Liquid | Clear colorless to yellow
Index of Refraction
n20/D 1.504
InChIKey
KMRMUZKLFIEVAO-IUCAKERBSA-N
SMILES
CC1(C)C2CC=C(C=O)C1C2
Storage condition
2-8°C
Safety Information
Personal Protective Equipment
Eyeshields;Gloves
Safety Phrases
23-24/25
RIDADR
NONH for all modes of transport
WGK Germany
2
RTECS
DT5180000
Articles7
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