CAS 5230-87-5|Anisatin

Introduction：Basic information about CAS 5230-87-5|Anisatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Anisatin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Anisatin
CAS Number	5230-87-5	Molecular Weight	328.31500
Density	1.149g/cm3	Boiling Point	251.2ºC at 760 mmHg
Molecular Formula	C₁₅H₂₀O₈	Melting Point	227-228ºC
MSDS	ChineseUSA	Flash Point	106.7ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	anisatin
Synonym	More Synonyms

Anisatin BiologicalActivity

Description	Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM[1].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor
In Vitro	Anisatin inhibits [3H]diazepam binding enhanced by either GABA or pentobarbital, without affecting the basal specific binding to rat brain membranes[1].
In Vivo	In mice, the LD50 reported for anisatin ranges from 0.76 to 1 mg/kg (po and ip)[1].
References	[1]. Ikeda T, et al. Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons. Br J Pharmacol. 1999;127(7):1567-1576. [2]. Bao X, et al. Bioavailability and Pharmacokinetics of Anisatin in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry. Biomed Res Int. 2020;2020:8835447. Published 2020 Dec 23.

Chemical & Physical Properties

Density	1.149g/cm3
Boiling Point	251.2ºC at 760 mmHg
Melting Point	227-228ºC
Molecular Formula	C₁₅H₂₀O₈
Molecular Weight	328.31500
Flash Point	106.7ºC
Exact Mass	328.11600
PSA	133.52000
Index of Refraction	1.486
InChIKey	GEVWHIDSUOMVRI-QWNPAUMXSA-N
SMILES	CC1CC(O)C2(O)C13CC(OC(=O)C3O)C(C)(O)C21COC1=O
Storage condition	?20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1314700

CHEMICAL NAME :: Spiro(6H-4,9a-methanocyclopent(d)oxocin-6,3'-oxetane) -2,2'(1H)-dione, 4a-beta,5,6a,7,8,9- hexahydro-5,9a-dimethyl-1-alpha,5-beta,6a-beta,7-beta -tetrahydroxy-

CAS REGISTRY NUMBER :: 5230-87-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H20-O8

MOLECULAR WEIGHT :: 328.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 44,1908,1996

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Skin and Appendages - hair

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,524,1959

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H330
Precautionary Statements	P260-P264-P284-P301 + P310-P310
Hazard Codes	T+
Risk Phrases	26/28
Safety Phrases	26-36/37/39-45
RIDADR	UN 2811 6.1 / PGII
RTECS	WH1314700

Synonyms

Fruit of illicium anisatum L.

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