CAS 39156-67-7|Dihydrocytochalasin B

Introduction：Basic information about CAS 39156-67-7|Dihydrocytochalasin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dihydrocytochalasin B BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles26
6. Synonyms

Common Name	Dihydrocytochalasin B
CAS Number	39156-67-7	Molecular Weight	481.62400
Density	1.194g/cm3	Boiling Point	727.474ºC at 760 mmHg
Molecular Formula	C₂₉H₃₉NO₅	Melting Point	203-205ºC
MSDS	ChineseUSA	Flash Point	393.762ºC
Symbol	GHS06, GHS08	Signal Word	Danger

Names

Name	dihydrocytochalasin b
Synonym	More Synonyms

Dihydrocytochalasin B BiologicalActivity

Description	Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis, causes cell rounding and a loss of actin microfilament bundles[2]. Dihydrocytochalasin B is related to transcytoplasmic movement of calcium by inhibiting active calcium transport and causes a Ca+increase in the mucosal scrapings[3].
Related Catalog	Signaling Pathways >>Cytoskeleton >>Arp2/3 ComplexResearch Areas >>Others
References	[1]. Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76(2):360-70. [2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51. [3]. Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30(1):253-62.

Description

Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis, causes cell rounding and a loss of actin microfilament bundles[2]. Dihydrocytochalasin B is related to transcytoplasmic movement of calcium by inhibiting active calcium transport and causes a Ca+increase in the mucosal scrapings[3].

Related Catalog

Signaling Pathways >>Cytoskeleton >>Arp2/3 ComplexResearch Areas >>Others

References

[1]. Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76(2):360-70.

[2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51.

[3]. Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30(1):253-62.

Chemical & Physical Properties

Density	1.194g/cm3
Boiling Point	727.474ºC at 760 mmHg
Melting Point	203-205ºC
Molecular Formula	C₂₉H₃₉NO₅
Molecular Weight	481.62400
Flash Point	393.762ºC
Exact Mass	481.28300
PSA	95.86000
LogP	4.04490
Index of Refraction	1.584
InChIKey	WIULKAASLBZREV-CJKMDAKDSA-N
SMILES	C=C1C(C)C2C(Cc3ccccc3)NC(=O)C23OC(=O)CCC(O)CCCC(C)CC=CC3C1O
Storage condition	-20℃

Safety Information

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300-H310-H330-H351
Precautionary Statements	P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T+,T
Risk Phrases	26/27/28-40
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
Hazard Class	6.1(a)

Articles26

Tetraploidization increases sensitivity to Aurora B kinase inhibition.

Cell Cycle 11(13) , 2567-77, (2012)

Aurora kinases are overexpressed in many cancers and are targets for anticancer drugs. The yeast homolog of Aurora B kinase, IPL1, was found to be a ploidy-specific lethality gene. Given that polyploi...

Centrifugal and chromatographic analyses of tryptophan and tyrosine uptake by red blood cells and GLUT1 proteoliposomes with permeability estimates and observations on dihydrocytochalasin B.

J. Biochem. Biophys. Methods 55(2) , 127-40, (2003)

We analyzed transport into liposomes and proteoliposomes, separated the free and internalized radioactively labeled substrates by size-exclusion chromatography (SEC) and observed a net influx owing to...

Degradation and recycling of the substrate-binding subunit of type II iodothyronine 5'-deiodinase in astrocytes.

J. Biol. Chem. 271(27) , 16369-74, (1996)

Thyroxine dynamically regulates levels of type II iodothyronine 5'-deiodinase (5'D-II) by modulating enzyme inactivation and targeting the enzyme to different pathways of internalization. 5'D-II is an...

Synonyms

2,3-Dihydro-cytochalasin B

21,22-dihydro-phomin

EINECS 254-324-4

21,22-Dihydrocytochalalsin B

CYTOCHALASIN B,DIHYDRO

21,22-dihydro-cytochalasin-B

dihydrocytocholasin-B

7(S),20(R)-dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione

DHCB

(7S,13E,16R,20R)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13-diene-1,23-dione

MFCD00010541

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