Introduction：Basic information about CAS 78964-85-9|Fosfomycin tromethamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fosfomycin tromethamine |
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| CAS Number | 78964-85-9 | Molecular Weight | 259.194 |
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| Density | / | Boiling Point | 357ºC at 760 mmHg |
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| Molecular Formula | C7H18NO7P | Melting Point | / |
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| MSDS | / | Flash Point | 169.7ºC |
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Names
| Name | Fosfomycin tromethamine |
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| Synonym | More Synonyms |
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Fosfomycin tromethamine BiologicalActivity
| Description | Fosfomycin tromethamine (MK-0955 tromethamine) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel). 2017 Oct 31;6(4). pii: E24. |
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Chemical & Physical Properties
| Boiling Point | 357ºC at 760 mmHg |
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| Molecular Formula | C7H18NO7P |
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| Molecular Weight | 259.194 |
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| Flash Point | 169.7ºC |
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| Exact Mass | 259.082092 |
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| PSA | 166.58000 |
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| InChIKey | QZJIMDIBFFHQDW-LMLSDSMGSA-N |
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| SMILES | CC1OC1P(=O)(O)O.NC(CO)(CO)CO |
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| Water Solubility | Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone. |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SZ9570000
- CAS REGISTRY NUMBER :
- 78964-85-9
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C4-H11-N-O3.C3-H7-O4-P
- MOLECULAR WEIGHT :
- 259.23
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988
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Safety Information
| Hazard Codes | Xn |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate |
| acide [(2R,3S)-3-méthyloxiran-2-yl]phosphonique - 2-amino-2-(hydroxyméthyl)propane-1,3-diol (1:1) |
| [(2R,3S)-3-Methyloxiran-2-yl]phosphonsäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1) |
| methyl)-1,3-propanediol(1:1) |
| (2R-cis)-(3-Methyloxiranyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)propane-1,3-diol (1:1) |
| Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) |
| fosfomycintrometamolsalt |
| FosfoMycin troMethaMine API |
| [(2R,3S)-3-Methyl-2-oxiranyl]phosphonic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) |
| Tromethamine fosfosmycin |
| tromethamine-fosfomycin |
| (1R,2S)-(1,2-Epoxypropyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1) |
| FOSFOMYCIN TROMETHAMOL |
| monuril |
| z1282 |
| FOSFOMYCIN TROMETAMOL |
| [(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1) |
| 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium hydrogen [(2R,3S)-3-methyloxiran-2-yl]phosphonate |
