Introduction：Basic information about CAS 108319-06-8|temafloxacin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | temafloxacin |
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| CAS Number | 108319-06-8 | Molecular Weight | 417.38100 |
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| Density | 1.427g/cm3 | Boiling Point | 608.9ºC at 760mmHg |
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| Molecular Formula | C21H18F3N3O3 | Melting Point | / |
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| MSDS | / | Flash Point | 322.1ºC |
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Names
| Name | 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid |
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| Synonym | More Synonyms |
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temafloxacin BiologicalActivity
| Description | Temafloxacin (TMFX) is a quinolone antimicrobial agent that has a broad antibacterial spectrum against Gram-positive, Gram-negative and anaerobic bacteria[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Temafloxacin has broad antimicrobial activity against gram-positive and gram-negative bacteria, including improved in vitro activity against Streptococcus pneumoniae, Mycoplasma hominis, and anaerobic bacteria, including Bacteroides fragilis[2]. |
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| In Vivo | Temafloxacin is a fluoroquinolone with a 7-8 hour half-life and rapid gastrointestinal absorption. With the exception of the central nervous system (CNS), Temafloxacin has excellent tissue and body fluid penetration and concentration[2]. |
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| References | [1]. S Matsuda, et al. Experimental and clinical studies of temafloxacin in the field of obstetrics and gynecology. Jpn J Antibiot. 1993 Jun;46(6):492-504. [2]. G A Pankey. Temafloxacin: an overview. Am J Med. 1991 Dec 30;91(6A):166S-172S. |
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Chemical & Physical Properties
| Density | 1.427g/cm3 |
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| Boiling Point | 608.9ºC at 760mmHg |
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| Molecular Formula | C21H18F3N3O3 |
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| Molecular Weight | 417.38100 |
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| Flash Point | 322.1ºC |
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| Exact Mass | 417.13000 |
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| PSA | 74.57000 |
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| LogP | 3.29810 |
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| Vapour Pressure | 1.11E-15mmHg at 25°C |
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| Index of Refraction | 1.603 |
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| InChIKey | QKDHBVNJCZBTMR-UHFFFAOYSA-N |
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| SMILES | CC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)CCN1 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VB1999065
- CHEMICAL NAME :
- 3-Quinolinecarboxylic acid, 1,4-dihydro-1-(2,4-difluorophenyl)-6-fluoro-7- (3-methyl-1-piperazinyl)-4-oxo-
- CAS REGISTRY NUMBER :
- 108319-06-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H18-F3-N3-O3
- MOLECULAR WEIGHT :
- 417.42
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 36400 mg/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in sodium
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 18200 mg/kg/26W-I
- TOXIC EFFECTS :
- Cardiac - EKG changes not diagnostic of specified effects Musculoskeletal - joints Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA - TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Bacteria - Bacillus subtilis
- DOSE/DURATION :
- 20 mg/L
- REFERENCE :
- AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 37,213,1993
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Synonyms
| [14C]-Temafloxacin |
| Temafloxacina [Spanish] |
| 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid |
| Temafloxacina |
| 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)-quinoline-3-carboxylic acid |
| Omniflox |
| Temafloxacinum [Latin] |
| Temafloxacine |
| 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid |
| Temafloxacinum |
| Temafloxacine [French] |
| Temafloxacin |
