CAS 2457-80-9|Adenylthiomethylpentose
Introduction：Basic information about CAS 2457-80-9|Adenylthiomethylpentose, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Adenylthiomethylpentose | ||
|---|---|---|---|
| CAS Number | 2457-80-9 | Molecular Weight | 297.333 |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 642.7±65.0 °C at 760 mmHg |
| Molecular Formula | C11H15N5O3S | Melting Point | 210-213ºC (dec.) |
| MSDS | ChineseUSA | Flash Point | 342.5±34.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 5'-S-methyl-5'-thioadenosine |
|---|---|
| Synonym | More Synonyms |
Adenylthiomethylpentose BiologicalActivity
| Description | 5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | 5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration[1]. |
| References | [1]. Avila MA, et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. |
Chemical & Physical Properties
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 642.7±65.0 °C at 760 mmHg |
| Melting Point | 210-213ºC (dec.) |
| Molecular Formula | C11H15N5O3S |
| Molecular Weight | 297.333 |
| Flash Point | 342.5±34.3 °C |
| Exact Mass | 297.089569 |
| PSA | 144.61000 |
| LogP | 0.67 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.843 |
| InChIKey | WUUGFSXJNOTRMR-IOSLPCCCSA-N |
| SMILES | CSCC1OC(n2cnc3c(N)ncnc32)C(O)C1O |
| Storage condition | −20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,653,1987
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,653,1987
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU7410000 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 5-Methylthioadenosine |
| 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β-D-Ribofuranose |
| β-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio- |
| Vitamin L2 |
| 5'-S-Methylthioadenosine |
| (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol |
| 5'-S-Methyl-5'-thioadenosine |
| 7-[Tetrahydro-3,4-dihydroxy-5-(methylmeracptomrthyl)-2-futyl]adenine |
| Adenosine, 5'-S-methyl-5'-thio- |
| 5'-Deoxy-5'-(methylthio)adenosine |
| MFCD00010533 |
| MTA,Methylthioadenosine |
| 5'-Deoxy-5'-Methylthioadenosine |
| Adenylthiomethylpentose |
| (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol |
