Introduction：Basic information about CAS 635-12-1|1,4-Anthracenedione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1,4-Anthracenedione |
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| CAS Number | 635-12-1 | Molecular Weight | 208.21200 |
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| Density | 1.328 g/cm3 | Boiling Point | 406ºC at 760 mmHg |
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| Molecular Formula | C14H8O2 | Melting Point | 217°C |
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| MSDS | / | Flash Point | 152ºC |
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Names
| Name | 1,4-Anthraquinone |
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| Synonym | More Synonyms |
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1,4-Anthracenedione BiologicalActivity
| Description | 1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
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| Target | DNA/RNA synthesis[1] |
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| In Vitro | 1,4-Anthraquinone (2.62 nM-1.6 μM; 4 days) induces significant antiproliferative and cytotoxic effects in L1210 cells after 4 days at 6.55 nM; inhibits cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4[1]. 1,4-Anthraquinone (40.96 nM-25 μM; 30 min; L1210 cells) inhibits nucleoside transport by 71 and 92% and DNA synthesis by 84 and 96% at 4 and 10 μM, respectively, and are both irreversible upon drug removal[1]. 1,4-Anthraquinone (0.1024-25 μM; 3 h) inhibits the rates of RNA and protein syntheses (IC50 = 2 μM) in a dose-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: L1210 cells Concentration: 2.62 nM-1.6 μM Incubation Time: 4 days Result: Induced significant antiproliferative and cytotoxic effects after 4 days at 6.55 nM. Cell Viability Assay[1] Cell Line: L1210 cells Concentration: 2.62 nM-1.6 μM Incubation Time: 4 days Result: Inhibited cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4. |
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Chemical & Physical Properties
| Density | 1.328 g/cm3 |
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| Boiling Point | 406ºC at 760 mmHg |
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| Melting Point | 217°C |
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| Molecular Formula | C14H8O2 |
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| Molecular Weight | 208.21200 |
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| Flash Point | 152ºC |
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| Exact Mass | 208.05200 |
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| PSA | 34.14000 |
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| LogP | 2.77500 |
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| Index of Refraction | 1.702 |
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| InChIKey | LSOTZYUVGZKSHR-UHFFFAOYSA-N |
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| SMILES | O=C1C=CC(=O)c2cc3ccccc3cc21 |
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Safety Information
| Safety Phrases | S22-S24/25 |
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| HS Code | 2914690090 |
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Customs
| HS Code | 2914690090 |
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| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| anthracene-1,4-dione |
| EINECS 211-228-7 |
| MFCD00013724 |
