Introduction：Basic information about CAS 84845-75-0|Niperotidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Niperotidine |
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| CAS Number | 84845-75-0 | Molecular Weight | 434.50900 |
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| Density | 1.268g/cm3 | Boiling Point | 566.324ºC at 760 mmHg |
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| Molecular Formula | C20H26N4O5S | Melting Point | / |
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| MSDS | / | Flash Point | 296.302ºC |
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Names
| Name | N-(1,3-benzodioxol-5-ylmethyl)-N'-[2-[[5-[(dimethylamino)methyl]furfuryl]thio]ethyl]-2-nitrovinylidenediamine |
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| Synonym | More Synonyms |
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Niperotidine BiologicalActivity
| Description | Niperotidine is a histamine H2-receptor antagonist. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Histamine ReceptorSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Metabolic Disease |
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| Target | histamine H2 receptor[1] |
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| In Vivo | Niperotidine (piperonyl-ranitidine) is a H2 blocking agent. Niperotidine is a H2-receptor antagonist structurally related to ranitidine. After oral administration, it reaches a plasmatic peak within 60-120 min and is eliminates either in the urine or in the faeces, with an enterohepatic circulation[2]. |
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| References | [1]. Palasciano G, et al. The effect of the H2-antagonist Niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Ital J Gastroenterol. 1990 Oct;22(5):291-4. [2]. Gasbarrini G, et al. Acute liver injury related to the use of Niperotidine. J Hepatol. 1997 Sep;27(3):583-6. |
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Chemical & Physical Properties
| Density | 1.268g/cm3 |
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| Boiling Point | 566.324ºC at 760 mmHg |
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| Molecular Formula | C20H26N4O5S |
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| Molecular Weight | 434.50900 |
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| Flash Point | 296.302ºC |
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| Exact Mass | 434.16200 |
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| PSA | 130.02000 |
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| LogP | 4.06310 |
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| Index of Refraction | 1.591 |
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| InChIKey | HXRSXEDVVARPHP-UHFFFAOYSA-N |
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| SMILES | CN(C)Cc1ccc(CSCCNC(=C[N+](=O)[O-])NCc2ccc3c(c2)OCO3)o1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Niperotidine |
| Piperotidine |
| N-(1,3-Benzodioxol-5-ylmethyl)-N'-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-2-nitro-1,1-ethenediamine |
| Piperonylranitidine |
| PiperotidineHCl |
| Piperonylranitidinehydrochloride |
