Introduction：Basic information about CAS 93117-08-9|5-Aminoisoquinolin-1(2H)-one, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Aminoisoquinolin-1(2H)-one |
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| CAS Number | 93117-08-9 | Molecular Weight | 160.173 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 477.3±45.0 °C at 760 mmHg |
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| Molecular Formula | C9H8N2O | Melting Point | / |
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| MSDS | / | Flash Point | 242.4±28.7 °C |
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Names
| Name | 5-Aminoisoquinolin-1(2H)-one |
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| Synonym | More Synonyms |
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5-Aminoisoquinolin-1(2H)-one BiologicalActivity
| Description | 5-AIQ (5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the therapy conditions associated with ischemia-reperfusion of the liver[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Epigenetics >>PARPSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
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| Target | PARP-1 |
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| In Vitro | 5-AIQ (5000 μg) significantly reduces the number of colonies of TA 98 without metabolic activation, and TA 98 and TA 1537 with metabolic activation[1]. |
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| In Vivo | 5-AIQ (150 and 250 mg/kg; p.o.; once) possess no significantly genotoxic in vivo system by micronucleus test[1]. 5-AIQ (3 mg/kg; p.o.; 5 min prior to onset of liver ischemia) reduces the tissue injury associated with ischemia-reperfusion of the liver[2]. Animal Model: Male mice[1] Dosage: 150 and 250 mg/kg Administration: Oral gavage; 150 and 250 mg/kg; once Result: Showed no increase of micronucleated polychromatic erythrocytes (MNPCE) in both 24 h and 48 h after both 125 and 250 mg/kg duration exposure as compared to the corresponding control. Animal Model: Anesthetised male Wistar rats with liver ischemia (for 30 minutes) and reperfusion (for 2 hours) [2] Dosage: 3 mg/kg Administration: Intravenous injection; 3 mg/kg; 5 min prior to onset of liver ischemia Result: Reduced PARP activation and showed less staining for ICAM-1. |
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| References | [1]. Vinod KR, Chandra S, Sharma SK. Evaluation of 5-aminoisoquinoline (5-AIQ), a novel PARP-1 inhibitor for genotoxicity potential in vitro and in vivo. Toxicol Mech Methods. 2010 Feb;20(2):90-5. [2]. Mota-Filipe H, et al. The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat. Med Sci Monit. 2002 Nov;8(11):BR444-53. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 477.3±45.0 °C at 760 mmHg |
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| Molecular Formula | C9H8N2O |
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| Molecular Weight | 160.173 |
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| Flash Point | 242.4±28.7 °C |
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| Exact Mass | 160.063660 |
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| PSA | 58.88000 |
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| LogP | -0.15 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.657 |
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| InChIKey | SVASVGVAQIVSEZ-UHFFFAOYSA-N |
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| SMILES | Nc1cccc2c(=O)[nH]ccc12 |
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Safety Information
Customs
| HS Code | 2933790090 |
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| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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Synonyms
| 5-Amino-1(2H)-isoquinolinone |
| 5-Amino-2H-isoquinolin-1-one |
| 5-Aminoisoquinolin-1(2H)-one |
| 1(2H)-Isoquinolinone, 5-amino- |
