Introduction：Basic information about CAS 975-77-9|Pericyclivine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pericyclivine |
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| CAS Number | 975-77-9 | Molecular Weight | 322.401 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 489.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H22N2O2 | Melting Point | / |
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| MSDS | / | Flash Point | 249.7±28.7 °C |
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Names
| Name | (+)-Pericyclivine |
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| Synonym | More Synonyms |
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Pericyclivine BiologicalActivity
| Description | Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Pericyclivine shows cytotoxicity against the P-388 cell culture system with an ED50 of 13 μg/mL[2]. |
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| References | [1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9. [2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 489.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H22N2O2 |
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| Molecular Weight | 322.401 |
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| Flash Point | 249.7±28.7 °C |
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| Exact Mass | 322.168121 |
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| PSA | 45.33000 |
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| LogP | 3.50 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.673 |
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| InChIKey | VXRAIAAMNNTQES-UHFFFAOYSA-N |
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| SMILES | CC=C1CN2C3CC1C(C(=O)OC)C2Cc1c3[nH]c2ccccc12 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VQ5835000
- CHEMICAL NAME :
- Sarpagan-17-oic acid, methyl ester, (16S)-
- CAS REGISTRY NUMBER :
- 975-77-9
- LAST UPDATED :
- 197905
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H20-N2-O2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04199
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Safety Information
Synonyms
| pericyclivine |
| Pericyclivin |
| Desformoakuammidin |
| Sarpagan-17-oic acid, methyl ester, (15α)- |
| Methyl (15α,19E)-sarpagan-17-oate |
| sarpagan-17-oic acid methyl ester |
| Deformoakuammidine |
