Introduction：Basic information about CAS 77-60-1|Tigogenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tigogenin |
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| CAS Number | 77-60-1 | Molecular Weight | 416.637 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 516.6±20.0 °C at 760 mmHg |
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| Molecular Formula | C27H44O3 | Melting Point | 202-204ºC |
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| MSDS | / | Flash Point | 266.2±21.8 °C |
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Names
| Name | (25R)-5.α.-Spirostan-3.β.-ol |
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| Synonym | More Synonyms |
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Tigogenin BiologicalActivity
| Description | Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| References | [1]. Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 516.6±20.0 °C at 760 mmHg |
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| Melting Point | 202-204ºC |
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| Molecular Formula | C27H44O3 |
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| Molecular Weight | 416.637 |
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| Flash Point | 266.2±21.8 °C |
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| Exact Mass | 416.329041 |
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| PSA | 38.69000 |
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| LogP | 6.21 |
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| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
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| Index of Refraction | 1.552 |
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| InChIKey | GMBQZIIUCVWOCD-MFRNJXNGSA-N |
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| SMILES | CC1CCC2(OC1)OC1CC3C4CCC5CC(O)CCC5(C)C4CCC3(C)C1C2C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- WH1443500
- CHEMICAL NAME :
- 5-alpha-Spirostan-3-beta-ol, (25R)-
- CAS REGISTRY NUMBER :
- 77-60-1
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C27-H44-O3
- MOLECULAR WEIGHT :
- 416.71
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29QKAZ "Toxins of Animal and Plant Origin, Proceedings International Symposium, 2nd, 1970," de Vries, A., and E. Kochva, eds., 3 vols., New York, Gordon and Breach Science Pub., 1971-73 Volume(issue)/page/year: 2,597,1972
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Safety Information
| Hazard Codes | Xi |
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| RTECS | WH1443500 |
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| Hazard Class | 2.3 |
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| HS Code | 2932999099 |
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Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 5α-Spirostan-3β-ol, (25R)- |
| TIGOGENIN |
| Tsosarsasaprgein |
| (3β,5α,25R)-Spirostan-3-ol |
| MFCD00067287 |
| Ticogenin |
| (25R)-5a-Spirostan-3b-ol |
| (25R)-5α-Spirostan-3β-ol |
| Sisalagenin |
| Trigonegenin B |
| EINECS 201-041-9 |
| Spirostan-3-ol, (3β,5α,25R)- |
