CAS 499-80-9|Lutidinic acid

Introduction：Basic information about CAS 499-80-9|Lutidinic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Lutidinic acid BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Lutidinic acid
CAS Number	499-80-9	Molecular Weight	167.12
Density	1.6±0.1 g/cm3	Boiling Point	574.8±35.0 °C at 760 mmHg
Molecular Formula	C₇H₅NO₄	Melting Point	243-246 °C
MSDS	/	Flash Point	301.4±25.9 °C

Names

Name	lutidinic acid
Synonym	More Synonyms

Lutidinic acid BiologicalActivity

Description	2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics[1][2][3].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Epigenetics >>Histone Demethylase
References	[1]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804. [2]. Gómez-Álvarez H, et al. Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresour Technol. 2022 Feb;346:126638. [3]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804.

Description

2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics[1][2][3].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Epigenetics >>Histone Demethylase

References

[1]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804.

[2]. Gómez-Álvarez H, et al. Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresour Technol. 2022 Feb;346:126638.

[3]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	574.8±35.0 °C at 760 mmHg
Melting Point	243-246 °C
Molecular Formula	C₇H₅NO₄
Molecular Weight	167.12
Flash Point	301.4±25.9 °C
Exact Mass	167.021851
PSA	87.49000
LogP	-0.19
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.628
InChIKey	MJIVRKPEXXHNJT-UHFFFAOYSA-N
SMILES	O=C(O)c1ccnc(C(=O)O)c1

Safety Information

Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S24/25
HS Code	29333999

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

2,4-Pyridinedicarboxylic acid

EINECS 207-892-2

MFCD00006296

2,4-Lutidinic Acid

Pyridine-2,4-dicarboxylic acid

Lutidinic acid

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