Introduction：Basic information about CAS 496794-70-8|HhAntag, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HhAntag |
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| CAS Number | 496794-70-8 | Molecular Weight | 450.91700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C24H23ClN4O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide |
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| Synonym | More Synonyms |
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HhAntag BiologicalActivity
| Description | HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway; antitumor agent.IC50 value:Target: Gli |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>GliResearch Areas >>Cancer |
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| References | [1]. Actis, Marcelo; Connelly, Michele C.; Mayasundari, Anand et al. A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription. Biopolymers (2011), 95(1), 24-30. [2]. Mahindroo, Neeraj; Connelly, Michele C.; Punchihewa, Chandanamali; et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorganic & Medicinal Chemistry (2010), 18(13), 4801-4811. [3]. Yauch, Robert L.; Gould, Stephen E.; Scales, Suzie J.; et al. A paracrine requirement for hedgehog signalling in cancer. Nature (London, United Kingdom) (2008), 455(7211), 406-410. |
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Chemical & Physical Properties
| Molecular Formula | C24H23ClN4O3 |
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| Molecular Weight | 450.91700 |
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| Exact Mass | 450.14600 |
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| PSA | 82.97000 |
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| LogP | 5.60280 |
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| InChIKey | UBHJFPVTEATUFS-UHFFFAOYSA-N |
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| SMILES | COc1cc(OC)cc(C(=O)Nc2ccc(Cl)c(-c3nc4ccc(N(C)C)cc4[nH]3)c2)c1 |
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| Storage condition | 2-8℃ |
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Synonyms
| CS-1233 |
| GLI1-mediated tranion inhibitor |
| HhAntag |
