CAS 23180-57-6|Paeoniflorin

Introduction：Basic information about CAS 23180-57-6|Paeoniflorin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Paeoniflorin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Preparation
7. Customs
8. Articles34
9. Synonyms

Common Name	Paeoniflorin
CAS Number	23180-57-6	Molecular Weight	480.462
Density	1.6±0.1 g/cm3	Boiling Point	690.2±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈O₁₁	Melting Point	/
MSDS	ChineseUSA	Flash Point	238.4±25.0 °C

Names

Name	Paeoniflorin
Synonym	More Synonyms

Paeoniflorin BiologicalActivity

Description	Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.Target: OthersPaeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease(PD) [1]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrogen [2]. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid-binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 microg/ mL (166.4 microM). To our knowledge, this is the first report on the induction of HSPs by herbal medicines [3].
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-HydroxylaseResearch Areas >>Neurological DiseaseNatural Products >>Terpenoids and Glycosides
References	[1]. Cao, B.Y., et al., Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway. J Ethnopharmacol, 2010. 131(1): p. 122-9. [2]. Takeuchi, T., et al., Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. Am J Chin Med, 1991. 19(1): p. 73-8. [3]. Yan, D., et al., Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones, 2004. 9(4): p. 378-89.

Description

Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.Target: OthersPaeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease(PD) [1]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrogen [2]. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid-binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 microg/ mL (166.4 microM). To our knowledge, this is the first report on the induction of HSPs by herbal medicines [3].

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-HydroxylaseResearch Areas >>Neurological DiseaseNatural Products >>Terpenoids and Glycosides

References

[1]. Cao, B.Y., et al., Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway. J Ethnopharmacol, 2010. 131(1): p. 122-9.

[2]. Takeuchi, T., et al., Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. Am J Chin Med, 1991. 19(1): p. 73-8.

[3]. Yan, D., et al., Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones, 2004. 9(4): p. 378-89.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	690.2±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈O₁₁
Molecular Weight	480.462
Flash Point	238.4±25.0 °C
Exact Mass	480.163147
PSA	164.37000
LogP	-0.42
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.683
InChIKey	YKRGDOXKVOZESV-WRJNSLSBSA-N
SMILES	CC12CC3(O)OC(O1)C1(COC(=O)c4ccccc4)C3CC21OC1OC(CO)C(O)C(O)C1O
Storage condition	room temp

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT1200000

CHEMICAL NAME :: Paeoniflorin

CAS REGISTRY NUMBER :: 23180-57-6

LAST UPDATED :: 199112

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H28-O11

MOLECULAR WEIGHT :: 480.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3530 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,899,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9530 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity)

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,899,1969

Safety Information

Hazard Codes	Xn,N,T,F
Risk Phrases	R22:Harmful if swallowed. R50:Very Toxic to aquatic organisms. R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed
Safety Phrases	S61-S45-S36/37
RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS	XZ3015000
HS Code	2932999099

Preparation

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles34

Chemical profiling and quantification of Gua-Lou-Gui-Zhi decoction by high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and ultra-performance liquid chromatography/triple quadrupole mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 986-987 , 69-84, (2015)

Gua-Lou-Gui-Zhi decoction (GLGZD) is a classical formula of traditional Chinese medicine, which has been commonly used to treat dysfunction after stroke, epilepsy and spinal cord injury. In this study...

[Treatment of premenstrual syndrome with Chinese medicine formula, baixiangdan capsule: implications for neuron viability and GABA(A) receptor modulation in rat cortex].

Zhongguo Zhong Yao Za Zhi 36(11) , 1508-11, (2011)

To explore the effects of Baixiangdan capsule (BXD), a Chinese medicinal formula, on the premenstrual syndrome (PMS) rats with Liver-qi invasion and the possible underlying micro-mechanisms.Wistar rat...

Detection of paeoniflorin and albiflorin by immunostaining technique using anti-paeoniflorin monoclonal antibody.

Phytochem. Anal. 24(2) , 124-8, (2013)

Paeoniae radix is one of the most important crude drugs used in Kampo medicines (KMs). A part of its pharmaceutical properties is due to the presence of paeoniflorin (PF) and albiflorin (AF).For the s...

Synonyms

paeoniflorine

Paeony root

Delmacinone

Paeonia moutan

peoniflorin

MFCD00869331

Paeonia lactiflora P,E,

Paeoniflorm

EINECS 245-476-2

PAEONIFLORIN(P)

,Peoniflorin

PACLITAXEL

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