Introduction：Basic information about CAS 23496-41-5|Peimine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Peimine |
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| CAS Number | 23496-41-5 | Molecular Weight | 431.651 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 568.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C27H45NO3 | Melting Point | 233-234ºC |
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| MSDS | ChineseUSA | Flash Point | 275.3±28.8 °C |
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Names
| Name | Peimine |
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| Synonym | More Synonyms |
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Peimine BiologicalActivity
| Description | Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.IC50 value:Target:Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB. |
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| Related Catalog | Signaling Pathways >>Others >>OthersNatural Products >>AlkaloidResearch Areas >>Inflammation/Immunology |
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| References | [1]. Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 568.4±50.0 °C at 760 mmHg |
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| Melting Point | 233-234ºC |
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| Molecular Formula | C27H45NO3 |
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| Molecular Weight | 431.651 |
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| Flash Point | 275.3±28.8 °C |
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| Exact Mass | 431.339935 |
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| PSA | 63.93000 |
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| LogP | 4.45 |
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| Vapour Pressure | 0.0±3.5 mmHg at 25°C |
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| Index of Refraction | 1.591 |
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| InChIKey | IUKLSMSEHKDIIP-BZMYINFQSA-N |
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| SMILES | CC1CCC2N(C1)CC1C3CC4C(CC(O)C5CC(O)CCC54C)C3CCC1C2(C)O |
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| Storage condition | 2-8℃ |
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Safety Information
| Hazard Codes | Xi |
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| Safety Phrases | 24/25 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| Peimine |
| Isodihydroimperialin |
| 5α-Cevane-3β,6α,20-triol |
| verticine |
| (3β,5α,6α)-Cevane-3,6,20-triol |
| Verticine,Zhebeinine,Wanpeinine A |
| ISODIHYDROIMPERIALINE |
| Dihydroisoimperialine |
| (3b,5a,6a)-cevane-3,6,20-triol |
| cevane-3,6,20-triol, (3b,5a,6a)- |
| Cevane-3,6,20-triol, (3β,5α,6α)- |
