CAS 27409-30-9|Picroside I
| Common Name | Picroside I | ||
|---|---|---|---|
| CAS Number | 27409-30-9 | Molecular Weight | 492.473 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 739.1±60.0 °C at 760 mmHg |
| Molecular Formula | C24H28O11 | Melting Point | 130 °C |
| MSDS | USA | Flash Point | 253.2±26.4 °C |
Names
| Name | picroside i |
|---|---|
| Synonym | More Synonyms |
Picroside I BiologicalActivity
| Description | Picroside I is the major ingredient of Picrorhiza kurroa. Picrorhiza kurroa is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II[1]. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATSignaling Pathways >>JAK/STAT Signaling >>STATResearch Areas >>Inflammation/Immunology |
| Target | STAT6 |
| References | [1]. Ganeshkumar Y, et al. Picroside I and Picroside II from Tissue Cultures of Picrorhiza kurroa. Pharmacognosy Res. 2017 Dec;9(Suppl 1):S53-S56. [2]. Sen Zhang, et al. Picroside I inhibits asthma phenotypes by regulating Tbet/GATA-3 ratio and Th1/Th2 balance in a murine model of asthma. Tropical Journal of Pharmaceutical Research September 2018; 17 (9): 1777-1782. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 739.1±60.0 °C at 760 mmHg |
| Melting Point | 130 °C |
| Molecular Formula | C24H28O11 |
| Molecular Weight | 492.473 |
| Flash Point | 253.2±26.4 °C |
| Exact Mass | 492.163147 |
| PSA | 167.67000 |
| LogP | -1.81 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.671 |
| InChIKey | XZGPUOQGERGURE-LUVHZPKESA-N |
| SMILES | O=C(C=Cc1ccccc1)OCC1OC(OC2OC=CC3C(O)C4OC4(CO)C23)C(O)C(O)C1O |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: soluble1mg/mL, clear, colorless |
Safety Information
| Hazard Codes | Xi |
|---|---|
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 29389090 |
Articles15
More Articles| Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells. Eur. J. Pharmacol. 406(2) , 203-8, (2000) Natural iridoid, picroside I (beta-D-glucopyranoside, 1a,1b,2,5a,6, 6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1, 2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate)) or II (beta-D-glucopyr... | |
| Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells. Life Sci. 71(15) , 1821-35, (2002) Picrosides I and II caused a concentration-dependent (> 0.1 microM) enhancement of basic fibroblast growth factor (bFGF, 2 ng/ml)-, staurosporine (10 nM)- and dibutyryl cyclic AMP (dbcAMP, 0.3 mM)-ind... | |
| De novo sequencing and characterization of Picrorhiza kurrooa transcriptome at two temperatures showed major transcriptome adjustments. BMC Genomics 13 , 126, (2012) Picrorhiza kurrooa Royle ex Benth. is an endangered plant species of medicinal importance. The medicinal property is attributed to monoterpenoids picroside I and II, which are modulated by temperature... |
Synonyms
| picroside-1 |
| PicrosideI |
| 2-Propenoic acid, 3-phenyl-, (1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-glucopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester, (2E)- |
| β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]- |
| 6'-O-trans-cinnamoylcatalpol |
| (1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-3-phenyl-2-propenoyl]-β-D-glucopyranoside |
| picrosides I |
| Picroside I |
| (1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-Glucopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl (2E)-3-phenylacrylate |
