CAS 477-90-7|Bergenin

Introduction：Basic information about CAS 477-90-7|Bergenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Bergenin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles36
6. Synonyms

Common Name	Bergenin
CAS Number	477-90-7	Molecular Weight	328.271
Density	1.6±0.1 g/cm3	Boiling Point	658.9±55.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₆O₉	Melting Point	237-240 °C(lit.)
MSDS	ChineseUSA	Flash Point	250.7±25.0 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	Bengenin
Synonym	More Synonyms

Bergenin BiologicalActivity

Description	Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 μM (antiplasmodial) [3]Target:In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2].In vivo: Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis [1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Phenylpropanoids
References	[1]. Gao XJ, et al. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015 Jun;38(3):1142-50. [2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54. [3]. Uddin G, et al. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Trop Biomed. 2014 Mar;31(1):143-8.

Description

Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 μM (antiplasmodial) [3]Target:In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2].In vivo: Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis [1].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Phenylpropanoids

References

[1]. Gao XJ, et al. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015 Jun;38(3):1142-50.

[2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54.

[3]. Uddin G, et al. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Trop Biomed. 2014 Mar;31(1):143-8.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	658.9±55.0 °C at 760 mmHg
Melting Point	237-240 °C(lit.)
Molecular Formula	C₁₄H₁₆O₉
Molecular Weight	328.271
Flash Point	250.7±25.0 °C
Exact Mass	328.079437
PSA	145.91000
LogP	0.05
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.655
InChIKey	YWJXCIXBAKGUKZ-HJJNZUOJSA-N
SMILES	COc1c(O)cc2c(c1O)C1OC(CO)C(O)C(O)C1OC2=O
Storage condition	?20°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UQ0337200

Articles36

Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb.

Bioorg. Med. Chem. 16 , 1337-44, (2008)

Saxifraga stolonifera, an evergreen dicotyledon, has been identified as an important resource in Chinese medicine due to its anticancer activity. In the present report, chemical components of S. stolo...

Simultaneous quantification of biomarkers bergenin and menisdaurin in the methanol extract of aerial parts of Flueggea virosa by validated HPTLC densitometric method.

J. Chromatogr. Sci. 53 , 824-9, (2015)

A simple, sensitive high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous quantification of biomarker bergenin and menisdaurin in the methanol extracts of aerial...

A novel lactone from Tripterospermum chinense.

Yao Xue Xue Bao 47(11) , 1517-20, (2012)

A novel lactone, tripterospermumcins E (1), along with four known compounds, sweroside (2), loganic acid (3), 8-epi-kingiside (4) and bergenin (5), were isolated from the aerial parts of Tripterosperm...

Synonyms

Vakerin

Ai Cha Su

Bergenitol

Bergenit

Peltophorin

CORYLOPSIN

(+)-Bergenin

3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one

4-Methoxy-2-[tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl]-a-resorcylic Acid d-Lactone

Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-

3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano[3,2-c][2]benzopyran-6(2H)-one

BERGENIN

Bergenin:Pyrano[3,2-c][2]benzopyran-6(2H)-one,3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, [2R-(2,3,4,4a, 10b)]-,

CUSCUTIN

Ardisic Acid B

MFCD00133120

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