Introduction：Basic information about CAS 524-17-4|Dauricine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dauricine |
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| CAS Number | 524-17-4 | Molecular Weight | 624.766 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 712.3±60.0 °C at 760 mmHg |
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| Molecular Formula | C38H44N2O6 | Melting Point | 115ºC |
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| MSDS | / | Flash Point | 384.6±32.9 °C |
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Names
| Name | dauricine |
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| Synonym | More Synonyms |
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Dauricine BiologicalActivity
| Description | Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/Immunology |
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| References | [1]. Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 712.3±60.0 °C at 760 mmHg |
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| Melting Point | 115ºC |
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| Molecular Formula | C38H44N2O6 |
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| Molecular Weight | 624.766 |
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| Flash Point | 384.6±32.9 °C |
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| Exact Mass | 624.319946 |
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| PSA | 72.86000 |
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| LogP | 6.61 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.601 |
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| InChIKey | AQASRZOCERRGBL-ROJLCIKYSA-N |
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| SMILES | COc1cc2c(cc1OC)C(Cc1ccc(Oc3cc(CC4c5cc(OC)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2 |
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| Storage condition | 2-8 °C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SM9490000
- CHEMICAL NAME :
- Phenol, 4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoqu inolinyl)methyl)-2-(4 -((1,2,3,4- tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)met hyl)phenoxy)-, (R-(R*,R*))-
- CAS REGISTRY NUMBER :
- 524-17-4
- LAST UPDATED :
- 198906
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C38-H44-N2-O6
- MOLECULAR WEIGHT :
- 624.84
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,182,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 185 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,419,1986
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Safety Information
Synonyms
| [R-(R*,R*)]-4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]-2-[4-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]phenol |
| Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]- |
| 6,6'-Di-O-Methyldauricoline |
| 4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-(4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenoxy)phenol |
| 4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-2-(4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}phenoxy)phenol |
| Dauricine |
| Dauricine (8CI) |
| Menispermum dauricum DC Extract |
