CAS 631-69-6|Beta-boswellic acid
| Common Name | Beta-boswellic acid | ||
|---|---|---|---|
| CAS Number | 631-69-6 | Molecular Weight | 456.700 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 556.0±50.0 °C at 760 mmHg |
| Molecular Formula | C30H48O3 | Melting Point | 130-135ºC |
| MSDS | ChineseUSA | Flash Point | 304.1±26.6 °C |
Names
| Name | β-Boswellic Acid |
|---|---|
| Synonym | More Synonyms |
Beta-boswellic acid BiologicalActivity
| Description | β-Boswellic acid is isolated from the gum resin of Boswellia serrate.β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation[1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>5-Lipoxygenase |
| References | [1]. Safayhi H, et al. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6. [2]. Shao Y, et al. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cellsin culture. Planta Med. 1998 May;64(4):328-31 |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 556.0±50.0 °C at 760 mmHg |
| Melting Point | 130-135ºC |
| Molecular Formula | C30H48O3 |
| Molecular Weight | 456.700 |
| Flash Point | 304.1±26.6 °C |
| Exact Mass | 456.360352 |
| PSA | 57.53000 |
| LogP | 9.38 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Index of Refraction | 1.555 |
| InChIKey | NBGQZFQREPIKMG-AKOQEMLPSA-N |
| SMILES | CC1CCC2(C)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C(=O)O)C5CCC43C)C2C1C |
| Storage condition | 2-8°C |
Safety Information
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2918199090 |
Customs
| HS Code | 2918199090 |
|---|---|
| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Articles27
More Articles| Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs. Bioorg. Med. Chem. Lett. 22 , 431-5, (2012) Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines... | |
| A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid. Eur. J. Med. Chem. 46 , 1356-66, (2011) Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical c... | |
| The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv. Ther. 28(10) , 894-906, (2011) Osteoarthritis is a chronic rheumatoid disease mediated by metalloproteinases and inflammatory cytokines. Methylsulfonylmethane (MSM) and boswellic acids (BA) each show promise in the treatment of inf... |
Synonyms
| b-Boswellic Acid |
| β-BOSWELLIC ACID |
| (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14bR)-3-Hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-4-picenecarboxylic acid |
| Urs-12-en-24-oic acid, 3-hydroxy-, (3α,9ξ)- |
| (3a,4b)-3-Hydroxyurs-12-en-23-oic Acid |
| (3α,9ξ)-3-Hydroxyurs-12-en-24-oic acid |
