CAS 34156-56-4|Phosphonoformic acid trisodium salt hexahydrate

Introduction：Basic information about CAS 34156-56-4|Phosphonoformic acid trisodium salt hexahydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles1
7. Synonyms

Common Name	Phosphonoformic acid trisodium salt hexahydrate
CAS Number	34156-56-4	Molecular Weight	300.042
Density	/	Boiling Point	490.7ºC
Molecular Formula	CH₁₂Na₃O₁₁P	Melting Point	/
MSDS	ChineseUSA	Flash Point	250.6ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	trisodium phosphonoformate hexahydrate
Synonym	More Synonyms

BiologicalActivity

Description	Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis
In Vitro	Phosphonoformic acid inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction[1]. Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2].

Chemical & Physical Properties

Boiling Point	490.7ºC
Molecular Formula	CH₁₂Na₃O₁₁P
Molecular Weight	300.042
Flash Point	250.6ºC
Exact Mass	299.981018
PSA	168.51000
InChIKey	ILRVASBWNRYBFD-UHFFFAOYSA-K
SMILES	O.O.O.O.O.O.O=C([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+]
Water Solubility	H2O: 0.1 g/mL hot, clear, colorless

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SY8300000

CHEMICAL NAME :: Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt, hexahydrate

CAS REGISTRY NUMBER :: 34156-56-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8500 mg/kg/17D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 139,324,1996

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SY8300000

Articles1

Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility.

J. Virol. 89(8) , 4636-44, (2015)

DNA polymerases of the Herpesviridae and bacteriophage RB69 belong to the α-like DNA polymerase family. In spite of similarities in structure and function, the RB69 enzyme is relatively resistant to f...

Synonyms

Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt, hydrate (1:3:6)

Foscarnet Sodium

Foscarnet sodium hexahydrate

Phosphonoformic acid trisodium salt hexahydrate

Sodium dioxidophosphinecarboxylate oxide hydrate (3:1:6)

Sodium phosphonatoformate hexahydrate

MFCD00150176

phosphonoformicacidtrisodiumsalthexahydrate

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