CAS 71376-34-6|Moniliformin, sodium salt
Introduction：Basic information about CAS 71376-34-6|Moniliformin, sodium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Moniliformin, sodium salt | ||
|---|---|---|---|
| CAS Number | 71376-34-6 | Molecular Weight | 120.03900 |
| Density | / | Boiling Point | 239.6ºC at 760 mmHg |
| Molecular Formula | C4HNaO3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 113ºC |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | sodium,3,4-dioxocyclobuten-1-olate |
|---|---|
| Synonym | More Synonyms |
Moniliformin, sodium salt BiologicalActivity
| Description | Moniliformin sodium salt is a potent, water-soluble mycotoxin isolate from Fusarium moniliforme. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Infection |
| In Vitro | Fusarium moniliforme NRRL 6322 produces about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. Several strains of Fusarium moniliforme produce in laboratory culture more than 800 mg of moniliformin per kg of growth substrate[1]. Monocytes-derived macrophages exposed to moniliformin during the differentiation process present a decrease of endocytosis ability, and a decrease of CD71 and HLA-DR expression[2]. |
| In Vivo | Moniliformin is less toxic to mice, with an LD50 of 20.9 mg per kg for the females and 29.1 mg per kg of body weight for the males. As in the case of the chicks, mice surviving the toxin demonstrated no ill effects; the mice or chicks that died became recumbent in 4 to 6 h after treatment and died within 24 h. In 4-day-old chicken embryos, a sharp LD50 of 2.8 μg per embryo is obtained with no overt gross teratogenic effects in the survivors[1]. Rats treated with the highest dose of moniliformin show decreased activity followed by acute heart failure and death. The rats of the lower doses (<9mg/kg b.w.) show no signs of toxicity. The daily intake of moniliformin strongly reduces the phagocytic activity of neutrophils in all dose groups. The decrease continued in the satellite group during the follow-up period, indicating a severe impact on the immune system and a LOAEL value of 3mg/kg b.w. for moniliformin. Moniliformin is rapidly excreted into urine, ranging between 20.2 and 31.5% daily and shows no signs of accumulation. The concentration of moniliformin in faeces is less than 2%, which suggests efficient absorption from the gastrointestinal tract[3]. |
| Animal Admin | Rats: Moniliformin is prepared in water. In this experiment, 5 dose groups (3, 6, 9, 12 and 15 mg/kg moniliformin b.w.) of test animals are exposed to moniliformin for 28 days. Each group consists of 5 male Sprague-Dawley rats. The dose groups are determined based on our acute toxicity study of MON in rats. In addition, a control group administered with filtered tap water and two satellite groups (dosed 12 and 15 mg/kg b.w. moniliformin) are used. The two satellite groups are kept alive for an additional 14 days without treatment to detect possible delayed toxic effects and to follow up recovery[3]. Mice: Sterile aqueous solutions of moniliformin are injected intraperitoneally (0.2 mL) into five female and five male white mice, weighing about 25 g each, at concentrations equivalent to 0, 20, 25, 30, and 35 mg per kg of body weight. The mice are observed over a 4-day period, and LD50 values are determined[1]. |
| References | [1]. Burmeister HR, et al. Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Appl Environ Microbiol. 1979 Jan;37(1):11-3. [2]. Ficheux AS, et al. Effects of beauvericin, enniatin b and moniliformin on human dendritic cells and macrophages: an in vitro study. Toxicon. 2013 Sep;71:1-10. [3]. Jonsson M, et al. Repeated dose 28-day oral toxicity study of moniliformin in rats. Toxicol Lett. 2015 Feb 17;233(1):38-44. |
Chemical & Physical Properties
| Boiling Point | 239.6ºC at 760 mmHg |
|---|---|
| Molecular Formula | C4HNaO3 |
| Molecular Weight | 120.03900 |
| Flash Point | 113ºC |
| Exact Mass | 119.98200 |
| PSA | 57.20000 |
| Storage condition | Store at 2-8 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
- REFERENCE :
- AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976- Volume(issue)/page/year: 37,11,1979
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | 25 |
| Safety Phrases | 45 |
| RIDADR | UN 2811 6.1/PG 2 |
| RTECS | GU1815000 |
Articles26
More Articles| Characterization and mycotoxigenic potential of Fusarium species in freshly harvested and stored sugar beet in Europe. Phytopathology 101(11) , 1330-7, (2011) Based on a 2-year field trial at two locations in Lower Saxony (Germany), 395 Fusarium isolates belonging to 13 species were collected from more than 3,000 sugar beet roots that were apparently health... | |
| Emerging fusarium-mycotoxins fusaproliferin, beauvericin, enniatins, and moniliformin: a review. Crit. Rev. Food Sci. Nutr 48(1) , 21-49, (2008) The contamination of foods and feed with mycotoxins is a commonly known problem. Intense investigations have been conducted to study the occurrence, toxicity, and recently also the prevention and deto... | |
| Mycotoxin production by isolates of Fusarium lactis from greenhouse sweet pepper (Capsicum annuum). Int. J. Food Microbiol. 151(2) , 150-6, (2011) Internal fruit rot, caused by Fusarium lactis, is an important disease of sweet pepper (Capsicum annuum) in Canadian greenhouses. Production of the mycotoxins fumonisin B₁ (FB₁), moniliformin (MON) an... |
Synonyms
| 3-CYCLOBUTENE-1,2-DIONE,3-HYDROXY-,SODIUM SALT |
| 1-Hydroxycyclobut-1-ene-3,4-dione |
| Moniliformin sodium salt from Fusarium proliferatum |
| 3-Hydroxy-3-cyclobutenedione sodium salt |
| Moniliformin sodium salt |
| 1-Hydroxycyclobut-1-ene-3,4-dione sodium salt |
| Moniliformin (sodium salt) |
