Introduction：Basic information about CAS 333-31-3|UNII:M73AI9718D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | UNII:M73AI9718D |
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| CAS Number | 333-31-3 | Molecular Weight | 240.138 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C8H18BrNO2 | Melting Point | 147-149ºC(lit.) |
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| MSDS | / | Flash Point | / |
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Names
| Name | methacholine bromide |
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| Synonym | More Synonyms |
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UNII:M73AI9718D BiologicalActivity
| Description | Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>mAChR |
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| In Vivo | Methacholine bromide (0.5 µg/kg plus 5 µg/kg/min for 30 min) induces bronchoconstriction in dogs[4]. Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 µg/kg; i.v.) in a a dose-dependent manner in mouse[5]. Animal Model: 9-week female BALB/c mice[6] Dosage: 0.03, 0.1, 0.3, 1 mg/kg Administration: I.v Result: Induced severe bronchoconstriction. |
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| References | [1]. Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18(3):171-176. [2]. Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10(1):4. Published 2009 Jan 23. [3]. Cockcroft DW. Methacholine challenge methods. Chest. 2008;134(4):678-680. [4]. Kabara S, et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91(3):379-84. [5]. Folkerts G, et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364(1):53-8. [6]. Vitorasso RL, et al. Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling. Exp Lung Res. 2020 Feb-Mar;46(1-2):23-31. |
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Chemical & Physical Properties
| Melting Point | 147-149ºC(lit.) |
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| Molecular Formula | C8H18BrNO2 |
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| Molecular Weight | 240.138 |
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| Exact Mass | 239.052078 |
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| PSA | 26.30000 |
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| InChIKey | MMVPLEUBMWUYIB-UHFFFAOYSA-M |
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| SMILES | CC(=O)OC(C)C[N+](C)(C)C.[Br-] |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26-36 |
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| HS Code | 2923900090 |
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Customs
| HS Code | 2923900090 |
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| Summary | 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| 2-Acetoxy-N,N,N-trimethyl-1-propanaminium bromide |
| METHYLCHOLINE BROMIDE |
| UNII:M73AI9718D |
| metacholine |
| ACETYL-B-METHYLCHOLINE BROMIDE |
| Acetyl-β-methylcholine bromide |
| Acetyl-beta-methylcholine bromide |
| O-Acetyl-β-methylcholine Bromide |
| MECHOLYL BROMIDE |
| ACETYL SS-METHYLCHOLINE BROMIDE |
| MFCD00011816 |
| 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (1:1) |
| Methacholine |
| 2-acetoxy-n,n,n-trimethylpropan-1-aminium bromide |
| EINECS 206-372-2 |
| 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide |
