Introduction：Basic information about CAS 49557-75-7|Copper Peptide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Copper Peptide |
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| CAS Number | 49557-75-7 | Molecular Weight | 340.378 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 831.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C14H24N6O4 | Melting Point | / |
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| MSDS | / | Flash Point | 456.4±34.3 °C |
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Names
| Name | Gly-His-Lys |
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| Synonym | More Synonyms |
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Copper Peptide BiologicalActivity
| Description | Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| In Vitro | Glycyl-L-histidyl-L-lysine and its copper complexes and saccharomyces/copper ferment on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line[1]. Glycyl-L-histidyl-L-lysine and its copper complexes decreases TNF-α-dependent IL-6 secretion in fibroblasts[1]. |
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| In Vivo | Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 1.5, 5, 50, 150, and 450 mg/kg; 10 times ) can stimulate mitotic activity of hepatocytes and dose-dependently suppresse immune reactivity[2]. Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 0.5, 5, and 50 μg/kg) can produce an anxiolytic effect in the elevated plus maze test[3]. |
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| References | [1]. Arkadiusz Gruchlik, et al. Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Pol Pharm. 2012 Nov-Dec;69(6):1303-6. [2]. M Yu Smakhtin, et al. Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor. Bull Exp Biol Med. 2002 Jun;133(6):586-7. [3]. I Bobyntsev, et al. Anxiolytic effects of Gly-His-Lys peptide and its analogs. Bull Exp Biol Med. 2015 Apr;158(6):726-8. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 831.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C14H24N6O4 |
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| Molecular Weight | 340.378 |
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| Flash Point | 456.4±34.3 °C |
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| Exact Mass | 340.185913 |
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| PSA | 176.22000 |
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| LogP | -2.24 |
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| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
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| Index of Refraction | 1.583 |
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| InChIKey | MVORZMQFXBLMHM-QWRGUYRKSA-N |
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| SMILES | NCCCCC(NC(=O)C(Cc1cnc[nH]1)NC(=O)CN)C(=O)O |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933290090 |
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Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Liver growth factor |
| Gly-L-His-L-Lys |
| Liver cell growth factor |
| L-Lysine, glycyl-L-histidyl- |
| Glycyl-L-Histidyl-L-Lysine |
| GHK Cu Copper Peptide |
| H-Gly-His-Lys-OH |
| glycyl-histidyl-lysine |
| ghk |
| Copper Peptide |
| Ahk-cu |
| Growth-modulating peptide |
| Gly-His-Lys-Cu |
| Copper Peptide (GHK-Cu) |
