Introduction：Basic information about CAS 490-78-8|2,5-Dihydroxyacetophenone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2,5-Dihydroxyacetophenone |
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| CAS Number | 490-78-8 | Molecular Weight | 152.147 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 329.2±27.0 °C at 760 mmHg |
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| Molecular Formula | C8H8O3 | Melting Point | 204-206 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 167.1±20.2 °C |
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Names
| Name | 2',5'-Dihydroxyacetophenone |
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| Synonym | More Synonyms |
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2,5-Dihydroxyacetophenone BiologicalActivity
| Description | 2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>MAPK/ERK Pathway >>ERKSignaling Pathways >>Stem Cell/Wnt >>ERK |
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| Target | ERK1 ERK2 NF-κB |
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| In Vitro | 2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells[1]. |
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| References | [1]. Han Y, et al. 2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatoryresponses in lipopolysaccharide-stimulated RAW264.7 macrophages. J Med Food. 2012 Jun;15(6):505-10. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 329.2±27.0 °C at 760 mmHg |
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| Melting Point | 204-206 °C(lit.) |
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| Molecular Formula | C8H8O3 |
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| Molecular Weight | 152.147 |
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| Flash Point | 167.1±20.2 °C |
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| Exact Mass | 152.047348 |
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| PSA | 57.53000 |
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| LogP | 1.59 |
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| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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| Index of Refraction | 1.595 |
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| InChIKey | WLDWSGZHNBANIO-UHFFFAOYSA-N |
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| SMILES | CC(=O)c1cc(O)ccc1O |
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| Water Solubility | insoluble |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AM7700000
- CHEMICAL NAME :
- Acetophenone, 2',5'-dihydroxy-
- CAS REGISTRY NUMBER :
- 490-78-8
- BEILSTEIN REFERENCE NO. :
- 0637903
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C8-H8-O3
- MOLECULAR WEIGHT :
- 152.16
- WISWESSER LINE NOTATION :
- QR CQ BV1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,140,1953
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Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi:Irritant |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | AM7700000 |
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| HS Code | 29145000 |
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Customs
| HS Code | 2914501900 |
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| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Articles1
More Articles
| 2,5-Dihydroxyacetophenone: a matrix for highly sensitive matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of proteins using manual and automated preparation techniques Wenzel, Thomas; Sparbier, Katrin; Mieruch, Thorsten; Kostrzewa, Markus Rapid Commun. Mass Spectrom. 20 , 785-789, (2005)
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Synonyms
| Ethanone, 1- (2,5-dihydroxyphenyl)- |
| 2,5-Dihydroxyphenyl methyl ketone,2-Acetyl-1,4-dihydroxybenzene,2-Acetylhydroquinone |
| 2’,5’-Dihydroxyacetophenone |
| 1-(2,5-Dihydroxyphenyl)ethanone |
| 2',5'-Dihydroxyacetophenone |
| 2',5'-Dihydroxy acetophenone |
| Quinacetophenone |
| EINECS 207-716-4 |
| 2-Acetylhydroquinone |
| 2‘,5‘-Dihydroxyacetophenone |
| Ethanone, 1-(2,5-dihydroxyphenyl)- |
| MFCD00002343 |
