CAS 128-76-7|4H-Dibenzo[de,g]quinolin-9-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-, (6aS)-

Introduction：Basic information about CAS 128-76-7|4H-Dibenzo[de,g]quinolin-9-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-, (6aS)-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

Common Name	4H-Dibenzo[de,g]quinolin-9-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-, (6aS)-
CAS Number	128-76-7	Molecular Weight	327.37400
Density	1.239g/cm3	Boiling Point	524.4ºC at 760mmHg
Molecular Formula	C₁₉H₂₁NO₄	Melting Point	/
MSDS	/	Flash Point	270.9ºC

Names

Name	1,2,10-trimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-9-ol

BiologicalActivity

Description	Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways[1].
Related Catalog	Research Areas >>Cancer
In Vivo	Laurotetanine ((+)-Laurotetanine; 20-60 mg/kg; p.o.; 每天，持续 21 天; SD 大鼠) 通过下调 MUC5AC 和 NF-κB 信号通路发挥抗哮喘作用。 Animal Model: Sprague Dawley (SD) rats (180-220g) [1] Dosage: 20, 40, and 60 mg/kg Administration: Oral administration; daily, for 21 days Result: Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages. Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ. Reduced serum IgE and histamine. Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.
References	[1]. Xin XX, et, al. Anti-asthmatic effect of laurotetanine extracted from Litsea cubeba (Lour.) Pers. root on ovalbumin-induced allergic asthma rats, and elucidation of its mechanism of action. TROP J PHARM RES. 2019:18(6).

Chemical & Physical Properties

Density	1.239g/cm3
Boiling Point	524.4ºC at 760mmHg
Molecular Formula	C₁₉H₂₁NO₄
Molecular Weight	327.37400
Flash Point	270.9ºC
Exact Mass	327.14700
PSA	59.95000
LogP	3.15670
Vapour Pressure	1.3E-11mmHg at 25°C
Index of Refraction	1.605
InChIKey	GVVXPMORGFYVOO-ZDUSSCGKSA-N
SMILES	COc1cc2c(cc1O)CC1NCCc3cc(OC)c(OC)c-2c31

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RB6025000

CHEMICAL NAME :: 6a-alpha-Noraporphin-9-ol, 1,2,10-trimethoxy-

CAS REGISTRY NUMBER :: 128-76-7

LAST UPDATED :: 198208

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H21-N-O4

MOLECULAR WEIGHT :: 327.41

WISWESSER LINE NOTATION :: T C6666 1A Q KM&TT&J EO1 FQ PO1 QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980

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