CAS 33162-17-3|2,3,4,4a,5,9B-hexahydro-2,8-dimethyl-1H-pipido[4,3-B]indola, dihydrochloride

Introduction：Basic information about CAS 33162-17-3|2,3,4,4a,5,9B-hexahydro-2,8-dimethyl-1H-pipido[4,3-B]indola, dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	2,3,4,4a,5,9B-hexahydro-2,8-dimethyl-1H-pipido[4,3-B]indola, dihydrochloride
CAS Number	33162-17-3	Molecular Weight	275.21700
Density	1.043g/cm3	Boiling Point	305.7ºC at 760mmHg
Molecular Formula	C₁₃H₂₀Cl₂N₂	Melting Point	/
MSDS	/	Flash Point	128.8ºC

Names

Name	2,8-Dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido-[4,3-b]indole dihydrochloride
Synonym	More Synonyms

BiologicalActivity

Description	Dicarbine dihydrochloride blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine dihydrochloride could be used in the schizophrenia and alcoholic psychosis studies[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease
References	[1]. Barkov NK, et al. [Effect of carbidine on conditioned defense reflexes]. Biull Eksp Biol Med. 1975 Apr;79(4):61-4. [2]. DICARBINE

Description

Dicarbine dihydrochloride blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine dihydrochloride could be used in the schizophrenia and alcoholic psychosis studies[1][2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease

References

[1]. Barkov NK, et al. [Effect of carbidine on conditioned defense reflexes]. Biull Eksp Biol Med. 1975 Apr;79(4):61-4.

[2]. DICARBINE

Chemical & Physical Properties

Density	1.043g/cm3
Boiling Point	305.7ºC at 760mmHg
Molecular Formula	C₁₃H₂₀Cl₂N₂
Molecular Weight	275.21700
Flash Point	128.8ºC
Exact Mass	274.10000
PSA	15.27000
LogP	3.88810
InChIKey	XWLFAMANDIWUKH-UHFFFAOYSA-N
SMILES	Cc1ccc2c(c1)C1CN(C)CCC1N2.Cl.Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU9990250

CHEMICAL NAME :: 5H-Pyrido(4,3-b)indole, 1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-, dihydrochloride

CAS REGISTRY NUMBER :: 33162-17-3

LAST UPDATED :: 199506

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H18-N2.2Cl-H

MOLECULAR WEIGHT :: 275.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 35,102,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 87 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic Behavioral - analgesia

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 6,512,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 57(2),4,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 87 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 34,268,1971

Safety Information

HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Carbidine

carbidine dihydrochloride

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