CAS 498-95-3|Nipecotic acid
| Common Name | Nipecotic acid | ||
|---|---|---|---|
| CAS Number | 498-95-3 | Molecular Weight | 129.157 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 265.8±33.0 °C at 760 mmHg |
| Molecular Formula | C6H11NO2 | Melting Point | 261ºC (dec.) |
| MSDS | USA | Flash Point | 114.5±25.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | nipecotic acid |
|---|---|
| Synonym | More Synonyms |
Nipecotic acid BiologicalActivity
| Description | Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
| Target | GABA Receptor[1] |
| In Vitro | Nipecotic acid (1 mM) activated inward unitary currents when applied to outside-out patches of paraventricular neurones[1]. |
| In Vivo | Nipecotic acid does not readily cross the blood-brain barrier (BBB)[2]. |
| References | [1]. Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8. [2]. Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 265.8±33.0 °C at 760 mmHg |
| Melting Point | 261ºC (dec.) |
| Molecular Formula | C6H11NO2 |
| Molecular Weight | 129.157 |
| Flash Point | 114.5±25.4 °C |
| Exact Mass | 129.078979 |
| PSA | 49.33000 |
| LogP | -0.04 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.479 |
| Storage condition | Store at 0-5°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TM6125380 |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles38
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| Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method. Clin. Chim. Acta 440 , 108-12, (2015) Pipecolic acid (PA) is an important biochemical marker for the diagnosis of peroxisomal disorders. PA is also a factor responsible for hepatic encephalopathy and a possible biomarker for pyridoxine-de... |
Synonyms
| hexahydronicotinic acid |
| MFCD00005992 |
| (±)-Nipecotic acid |
| (±)-Piperidine-3-carboxylic acid |
| Nipecotic acid |
| UNII:1U1QTN40SY |
| Piperidine-3-carboxylic acid |
| EINECS 207-873-9 |
| (±)-3-Piperidine carboxylic acid |
| 3-Piperidinecarboxylic acid |
| H-DL-Nip-OH |
