Introduction：Basic information about CAS 821794-90-5|CMK, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CMK |
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| CAS Number | 821794-90-5 | Molecular Weight | 358.822 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 647.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C18H19ClN4O2 | Melting Point | / |
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| MSDS | / | Flash Point | 345.4±31.5 °C |
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Names
| Name | 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloroethanone |
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| Synonym | More Synonyms |
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CMK BiologicalActivity
| Description | CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>Ribosomal S6 Kinase (RSK)Research Areas >>Cancer |
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| In Vitro | CMK inhibits the growth of Cdc5 (L158G) with IC50 of 36 nM, greater than 30 μM for wild type Cdc5. CMK exhibits a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain with an IC50 of 1.1 μM. CMK inhibition of Cdc5 (L158G) leads to a first cell cycle anaphase arrest and delay in anaphase spindle migration[1]. |
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| Kinase Assay | For Cdc5 kinase assays, Spc72-TAP is isolated from cell extract by pulldown with IgG sepharose or rabbit IgG coupled to M-270 epoxy dynabeads and incubated in kinase buffer (25 mM HEPES, pH 8.0, 60 mM KCl, 15 mM MnCl2, 100 μg/mL BSA, 80 nM microcystin, 1mM DTT, 100 μM 200 μCi/mL [γ-32P]ATP) in the absence or presence of 100 ng purified baculovirus expressed 6xHis-Cdc5. 32P incorporation is visualized on a Typhoon PhosphorImager, and images are processed using ImageQuant software. |
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| References | [1]. Snead JL, et al. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov;14(11):1261-72. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 647.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C18H19ClN4O2 |
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| Molecular Weight | 358.822 |
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| Flash Point | 345.4±31.5 °C |
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| Exact Mass | 358.119659 |
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| PSA | 94.03000 |
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| LogP | 1.55 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.670 |
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| InChIKey | PELFTNQHGSITLB-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(-c2c(C(=O)CCl)n(CCCO)c3ncnc(N)c23)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro- |
| CS-0404 |
| 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloroethanone |
| CMK| |
| 1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl)-2-chloroethanone |
| CMK |
