Introduction：Basic information about CAS 64421-28-9|Shanzhiside methylester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Shanzhiside methylester |
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| CAS Number | 64421-28-9 | Molecular Weight | 406.382 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 651.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C17H26O11 | Melting Point | 90ºC (dec.) |
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| MSDS | / | Flash Point | 233.0±25.0 °C |
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Names
| Name | shanzhiside methyl ester |
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| Synonym | More Synonyms |
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Shanzhiside methylester BiologicalActivity
| Description | Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Glucagon Receptor |
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| Target | IC50: GLP-1 receptor[1] |
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| In Vivo | Shanzhiside methyl ester exerts dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg[1]. |
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| References | [1]. Fan H, et al. Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.Neuropharmacology. 2016 Feb;101:98-109. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 651.4±55.0 °C at 760 mmHg |
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| Melting Point | 90ºC (dec.) |
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| Molecular Formula | C17H26O11 |
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| Molecular Weight | 406.382 |
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| Flash Point | 233.0±25.0 °C |
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| Exact Mass | 406.147522 |
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| PSA | 175.37000 |
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| LogP | -3.25 |
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| Vapour Pressure | 0.0±4.4 mmHg at 25°C |
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| Index of Refraction | 1.621 |
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| InChIKey | KKSYAZCUYVRKML-UWVIJCLTSA-N |
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| SMILES | COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C2C1C(O)CC2(C)O |
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Safety Information
Synonyms
| Methyl (1S,4aS,5R,7S,7aS)-1-(β-D-glucopyranosyloxy)-5,7-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate |
| shanziside Me-ester |
| shanziside methyl ester |
| shanzhiside methy ester |
| Shanzhiside methylester |
| Shanzhiside methyl ester |
| hanzhiside Methyl ester |
| Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5,7-dihydroxy-7-methyl-, methyl ester, (1S,4aS,5R,7S,7aS)- |
| Shaniside methyl ester |
| shanzhiside Me ester |
