Introduction：Basic information about CAS 490-59-5|Alloxazine;Isoalloxazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alloxazine;Isoalloxazine |
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| CAS Number | 490-59-5 | Molecular Weight | 214.18000 |
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| Density | 1.509g/cm3 | Boiling Point | / |
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| Molecular Formula | C10H6N4O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | alloxazine |
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| Synonym | More Synonyms |
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Alloxazine;Isoalloxazine BiologicalActivity
| Description | Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Adenosine Receptor |
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| Target | IC50: 2.9 μM (AMP)[1] |
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| In Vitro | Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1]. Cell Viability Assay[1] Cell Line: PGT-β cells Concentration: 0-30 μM Incubation Time: 20 min Result: Inhibited the cyclic AMP generation concentration-dependently with an IC IC50 of 2.9 μM. |
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| In Vivo | Alloxazine (1 µmol/L, 0-20 min) suppresses NECA-induced vasodilation[2]. Animal Model: 250–320 g male Sprague-Dawley rats[2] Dosage: 1 µmol/L Administration: Cortical surface suffusion; 1 µmol/L once Result: Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L. |
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| References | [1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14. [2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44. |
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Chemical & Physical Properties
| Density | 1.509g/cm3 |
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| Molecular Formula | C10H6N4O2 |
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| Molecular Weight | 214.18000 |
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| Exact Mass | 214.04900 |
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| PSA | 91.50000 |
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| LogP | 0.15960 |
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| Index of Refraction | 1.699 |
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| InChIKey | HAUGRYOERYOXHX-UHFFFAOYSA-N |
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| SMILES | O=c1[nH]c(=O)c2nc3ccccc3nc2[nH]1 |
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| Storage condition | -20℃ |
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Safety Information
| WGK Germany | 3 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Alloxazin |
| 1H-benzo[g]pteridine-2,4-dione |
| Alloxazine |
