CAS 18323-58-5|4-Methylumbelliferyl Oleate
| Common Name | 4-Methylumbelliferyl Oleate | ||
|---|---|---|---|
| CAS Number | 18323-58-5 | Molecular Weight | 440.61500 |
| Density | 1.023g/cm3 | Boiling Point | 571.5ºC at 760mmHg |
| Molecular Formula | C28H40O4 | Melting Point | 37-38ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 281.3ºC |
Names
| Name | 4-methylumbelliferyl oleate |
|---|---|
| Synonym | More Synonyms |
4-Methylumbelliferyl Oleate BiologicalActivity
| Description | 4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. 4-Methylumbelliferyl oleate is cleaved by lipases, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm)[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| In Vitro | The inhibitory activity against pancreatic lipase was measured using 4-Methylumbelliferyl (4-MU) oleate as a substrate. The reaction mixture consisted of 50 µL 0.1 mM 4-MU oleate, 20 µL McIlvane buffer (0.1 M citrate-Na2 HPO4, pH 7.4), and 5 µL of sample solution. Porcine pancreatic lipase (25 µL) was added to the reaction mixture and the final volume was adjusted to 0.1 ml. After the mixture was incubated at 37℃ for 10 min, the amount of 4-MU released by the lipase was measured using a fluorescence multi-detection reader at an excitation wavelength of 320 nm and an emission wavelength of 450 nm[1]. |
| References | [1]. Zhang J, et al. Pancreatic lipase inhibitory activity of taraxacum officinale in vitro and in vivo. Nutr Res Pract. 2008 Winter;2(4):200-3. [2]. Koster JF, et al. Study of the hydrolysis of 4-methylumbelliferyl oleate by acid lipase and cholesteryl oleate by acid cholesteryl esterase in human leucocytes, fibroblasts and liver. Biochim Biophys Acta. 1980 Apr 18;618(1):98-105. |
Chemical & Physical Properties
| Density | 1.023g/cm3 |
|---|---|
| Boiling Point | 571.5ºC at 760mmHg |
| Melting Point | 37-38ºC(lit.) |
| Molecular Formula | C28H40O4 |
| Molecular Weight | 440.61500 |
| Flash Point | 281.3ºC |
| Exact Mass | 440.29300 |
| PSA | 56.51000 |
| LogP | 8.04430 |
| Vapour Pressure | 4.53E-13mmHg at 25°C |
| Index of Refraction | 1.515 |
| InChIKey | NKQFKJYKCVDLPT-KHPPLWFESA-N |
| SMILES | CCCCCCCCC=CCCCCCCCC(=O)Oc1ccc2c(C)cc(=O)oc2c1 |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932209090 |
Customs
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles26
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Synonyms
| 4-MethylumbelliferylOleateA.R. |
| OLEIC ACID-4-METHYLUMBELLIFERYL ESTER |
| Einecs 242-210-7 |
| 4-Methylumbelliferone oleate |
| 7-Hydroxy-4-MethylcouMarin Oleate |
| MFCD00076095 |
| Oleic acid 4-methylumbelliferyl ester |
| 4-methyl-2-oxo-2H-1-benzopyran-7-yl oleate |
| Oleoyl 4-MethyluMbelliferone |
