CAS 71861-76-2|1-Acetyl-3-o-toluyl-5-fluorouracil

Introduction：Basic information about CAS 71861-76-2|1-Acetyl-3-o-toluyl-5-fluorouracil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name1-Acetyl-3-o-toluyl-5-fluorouracil
CAS Number71861-76-2Molecular Weight290.24700
Density1.44g/cm3Boiling Point408.8ºC at 760 mmHg
Molecular FormulaC14H11FN2O4Melting Point/
MSDS/Flash Point201.1ºC

Names

Name1-acetyl-5-fluoro-3-(2-methylbenzoyl)pyrimidine-2,4-dione
SynonymMore Synonyms

1-Acetyl-3-o-toluyl-5-fluorouracil BiologicalActivity

Description1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Cancer
In VivoOral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1].
Animal AdminMice: Of the ten groups of tumor bearing mice, subcutaneous administration of 5-fluorouracil or 1-Acetyl-3-o-toluyl-5-fluorouracil is made at a dose of 0.2, 0.4 and 0.6 mmol/kg/d on six groups in the buttock region. In three groups, oil solution of 1-Acetyl-3-o-toluyl-5-fluorouracil is administered orally with a stomach tube at a dose of 0.2, 0.4 and 0.6 mmol/kg/d. The remaining group is used as tumor bearing control. During the period of the experiment, body weight is measured every 3 day and the long and short diameters of the tumor are measured daily[1].
References

[1]. Yata N, et al. Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration. J Pharmacobiodyn. 1985 Apr;8(4):264-9.

Chemical & Physical Properties

Density1.44g/cm3
Boiling Point408.8ºC at 760 mmHg
Molecular FormulaC14H11FN2O4
Molecular Weight290.24700
Flash Point201.1ºC
Exact Mass290.07000
PSA78.14000
LogP0.80610
Index of Refraction1.609
InChIKeyDRXHAKVGNKHFMB-UHFFFAOYSA-N
SMILESCC(=O)n1cc(F)c(=O)n(C(=O)c2ccccc2C)c1=O
Storage condition2-8℃

Synonyms

A-OT
1-Acetyl-5-fluoro-3-(2-methylbenzoyl)-2,4-(1H,3H)-pyrimidinedione
N(sub 1)-Acetyl-N(sub 3)-o-toluyl-5-fluorouracil
Atofluding
1-Acetyl-3,2-toluyl-5-fluorouracil
2,4(1H,3H)-Pyrimidinedione,1-acetyl-5-fluoro-3-(2-methylbenzoyl)
1-Acetyl-3-o-toluyl-5-fluorouracil
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