CAS 82079-32-1|Thiolactomycin

Introduction：Basic information about CAS 82079-32-1|Thiolactomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Thiolactomycin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Thiolactomycin
CAS Number	82079-32-1	Molecular Weight	210.29300
Density	1.214g/cm3	Boiling Point	319.2ºC at 760 mmHg
Molecular Formula	C₁₁H₁₄O₂S	Melting Point	/
MSDS	/	Flash Point	146.8ºC

Names

Name	(2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dienyl]thiophen-3-one
Synonym	More Synonyms

Thiolactomycin BiologicalActivity

Description	Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. Price AC, et al. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem. 2001 Mar 2;276(9):6551-9. [2]. Slayden RA, et al. Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother. 1996 Dec;40(12):2813-9.

Description

Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial

References

[1]. Price AC, et al. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem. 2001 Mar 2;276(9):6551-9.

[2]. Slayden RA, et al. Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother. 1996 Dec;40(12):2813-9.

Chemical & Physical Properties

Density	1.214g/cm3
Boiling Point	319.2ºC at 760 mmHg
Molecular Formula	C₁₁H₁₄O₂S
Molecular Weight	210.29300
Flash Point	146.8ºC
Exact Mass	210.07100
PSA	62.60000
LogP	2.98280
Index of Refraction	1.632
InChIKey	SYQNUQSGEWNWKV-XUIVZRPNSA-N
SMILES	C=CC(C)=CC1(C)SC(=O)C(C)=C1O

Synonyms

[R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone

2(5H)-Thiophenone,3,5-dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-,(R-(E))

Antibiotic 2-200

MFCD01940028

TLM

(+)-Thiolactomycin

(R,E)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dienyl)thiophen-2(5H)-one

(R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone

(5R)-4-hydroxy-3,5-dimethyl-5-(2-methyl-buta-1,3-dienyl)-5-H-thiophen-2-one

(R)-(+)-Thiolactomycin

5R-Thiolactomycin

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