CAS 81161-17-3|Esmolol hydrochloride
Introduction：Basic information about CAS 81161-17-3|Esmolol hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Esmolol hydrochloride | ||
|---|---|---|---|
| CAS Number | 81161-17-3 | Molecular Weight | 331.835 |
| Density | 1.026 | Boiling Point | 430.2ºC at 760 mmHg |
| Molecular Formula | C16H26ClNO4 | Melting Point | 48-50ºC |
| MSDS | USA | Flash Point | 214ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | esmolol hydrochloride |
|---|---|
| Synonym | More Synonyms |
Esmolol hydrochloride BiologicalActivity
| Description | Esmolol Hydrochloride is a beta adrenergic receptor blocker.Target: Adrenergic receptorEsmolol Hydrochloride is the hydrochloride salt form of Esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, Esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Cardiovascular Disease |
Chemical & Physical Properties
| Density | 1.026 |
|---|---|
| Boiling Point | 430.2ºC at 760 mmHg |
| Melting Point | 48-50ºC |
| Molecular Formula | C16H26ClNO4 |
| Molecular Weight | 331.835 |
| Flash Point | 214ºC |
| Exact Mass | 331.155029 |
| PSA | 67.79000 |
| LogP | 2.72280 |
| InChIKey | GEKNCWBANDDJJL-UHFFFAOYSA-N |
| SMILES | COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1.Cl |
| Storage condition | −20°C |
| Water Solubility | Slightly soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 775 ug/kg/14M-C
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 22,484,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 71 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 93 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 560 mg/kg/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R52/53 |
| Safety Phrases | 61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | - |
| RTECS | DA8346000 |
| HS Code | 2922199090 |
Customs
| HS Code | 2922199090 |
|---|---|
| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles2
More Articles| Esmolol: immunomodulator in pyelonephritis by Pseudomonas aeruginosa. J. Surg. Res. 198 , 175-84, (2015) Based on previous animal studies showing promising immunomodulatory efficacy esmolol, a selective β1-blocker, it was assumed that administration of esmolol in experimental pyelonephritis by multidrug-... | |
| Effect of Retroperitoneal Lavage with Normal Saline Containing Adrenaline on Carbon Dioxide Absorption in Patients Undergoing Retroperitoneal Laparoscopic Surgery. J Laparoendosc Adv Surg Tech A 25 , 903-7, (2015) To determine the effect of lavage with adrenaline solution on CO2 absorption during retroperitoneal laparoscopic surgery.Sixty patients scheduled to undergo retroperitoneal laparoscopic surgery were d... |
Synonyms
| esmolol hcl |
| Benzenepropanoic acid, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, methyl ester, hydrochloride (1:1) |
| Esmolol Hydrochloride |
| EsmololHclC16H25No4Hcl |
| 3-(4-{2-hydroxy-3-[(1-méthyléthyl)amino]propoxy}phényl)propanoate de méthyle chlorhydrate |
| Methyl-3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoathydrochlorid |
| methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate hydrochloride (1:1) |
| benzenepropanoic acid, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, methyl ester, hydrochloride |
| MFCD00941432 |
| methyl 3-(4-{2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl)propanoate hydrochloride |
| Methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate hydrochloride |
| UNII:V05260LC8D |
| Methyl 3-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}propanoate hydrochloride (1:1) |
| Methyl 3-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}propanoate hydrochloride |
| Brevibloc |
| Methyl-3-(4-{2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl)propanoathydrochlorid |
| EsMolol Hcl API |
