CAS 106627-54-7|N-Hydroxysulfosuccinimide sodium
| Common Name | N-Hydroxysulfosuccinimide sodium | ||
|---|---|---|---|
| CAS Number | 106627-54-7 | Molecular Weight | 217.132 |
| Density | / | Boiling Point | / |
| Molecular Formula | C4H4NNaO6S | Melting Point | 250 °C (dec.)(lit.) |
| MSDS | USA | Flash Point | / |
Names
| Name | N-Hydroxysulfosuccinimide sodium salt |
|---|---|
| Synonym | More Synonyms |
N-Hydroxysulfosuccinimide sodium BiologicalActivity
| Description | N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
| Target | Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |
Chemical & Physical Properties
| Melting Point | 250 °C (dec.)(lit.) |
|---|---|
| Molecular Formula | C4H4NNaO6S |
| Molecular Weight | 217.132 |
| Exact Mass | 216.965698 |
| PSA | 123.19000 |
| InChIKey | RPENMORRBUTCPR-UHFFFAOYSA-M |
| SMILES | O=C1CC(S(=O)(=O)[O-])C(=O)N1O.[Na+] |
| Storage condition | 0-6°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2925190090 |
Customs
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 3-Pyrrolidinesulfonic acid, 1-hydroxy-2,5-dioxo-, sodium salt (1:1) |
| Sodium 1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate |
| Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt |
| N-Hydroxysulfosuccinimide sodiumsalt |
| Sodium 1-hydroxy-2,5-dioxo-3-pyrrolidinesulfonate |
| sodium,1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate |
| N-Hydroxysulfosuccinimide Sodium Salt |
| MFCD00217065 |
