CAS 16357-59-8|N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

Introduction：Basic information about CAS 16357-59-8|N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles35
7. Synonyms

Common Name	N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
CAS Number	16357-59-8	Molecular Weight	247.290
Density	1.2±0.1 g/cm3	Boiling Point	355.9±42.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₇NO₃	Melting Point	62-67 °C(lit.)
MSDS	ChineseUSA	Flash Point	169.0±27.9 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	355.9±42.0 °C at 760 mmHg
Melting Point	62-67 °C(lit.)
Molecular Formula	C₁₄H₁₇NO₃
Molecular Weight	247.290
Flash Point	169.0±27.9 °C
Exact Mass	247.120850
PSA	38.77000
LogP	2.98
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.565
InChIKey	GKQLYSROISKDLL-UHFFFAOYSA-N
SMILES	CCOC(=O)N1c2ccccc2C=CC1OCC
Storage condition	2-8°C
Water Solubility	insoluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB2010000

CHEMICAL NAME :: 1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester

CAS REGISTRY NUMBER :: 16357-59-8

BEILSTEIN REFERENCE NO. :: 0533048

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H17-N-O3

MOLECULAR WEIGHT :: 247.32

WISWESSER LINE NOTATION :: T66 BN CHJ BVO2 CO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,49,1971

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S22-S24/25-S36/37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	VB2010000
HS Code	29334990

Customs

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles35

Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex.

Neuropharmacology 89 , 204-14, (2014)

FADD is a crucial adaptor of death receptors that can engage apoptosis or survival actions (e.g. neuroplasticity) through its phosphorylated form (p-FADD). Although FADD was shown to participate in re...

Dengue type four viruses with E-Glu345Lys adaptive mutation from MRC-5 cells induce low viremia but elicit potent neutralizing antibodies in rhesus monkeys.

PLoS ONE 9(6) , e100130, (2014)

Knowledge of virulence and immunogenicity is important for development of live-attenuated dengue vaccines. We previously reported that an infectious clone-derived dengue type 4 virus (DENV-4) passaged...

Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles.

J. Cell Biol. 151 , 507-18, (2000)

In higher eukaryotes, phospholipid and cholesterol synthesis occurs mainly in the endoplasmic reticulum, whereas sphingomyelin and higher glycosphingolipids are synthesized in the Golgi apparatus. Lip...

Synonyms

1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline

1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester

Ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate

2-Ethoxy-1(2H)-quinolinecarboxylic Acid Ethyl Ester

EEDQ

EINECS 240-418-2

Ethyl-2-ethoxychinolin-1(2H)-carboxylat

ethyl 2-ethoxy-2H-quinoline-1-carboxylate

2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ)

ethyl 2-ethoxyquinoline-1(2H)-carboxylate

MFCD00006703

Ethyl 2-ethoxy-1(2H)-quinolinecarboxylate

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