CAS 581-88-4|DEBRISOQUIN SULFATE
Introduction：Basic information about CAS 581-88-4|DEBRISOQUIN SULFATE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DEBRISOQUIN SULFATE | ||
|---|---|---|---|
| CAS Number | 581-88-4 | Molecular Weight | 224.27 |
| Density | / | Boiling Point | 309.8ºC at 760 mmHg |
| Molecular Formula | C10H13N3.1/2H2O4S | Melting Point | 278-280°, 284-285° or 266-268° (H2O) |
| MSDS | ChineseUSA | Flash Point | 141.1ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | debrisoquin sulfate |
|---|---|
| Synonym | More Synonyms |
DEBRISOQUIN SULFATE BiologicalActivity
| Description | Debrisoquin (Isocaramidine) hemisulfate is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin hemisulfate can be used for antiviral research[1]. |
|---|---|
| Related Catalog | Research Areas >>Infection |
| Target | Human Endogenous Metabolite |
Chemical & Physical Properties
| Boiling Point | 309.8ºC at 760 mmHg |
|---|---|
| Melting Point | 278-280°, 284-285° or 266-268° (H2O) |
| Molecular Formula | C10H13N3.1/2H2O4S |
| Molecular Weight | 224.27 |
| Flash Point | 141.1ºC |
| Exact Mass | 448.189270 |
| PSA | 189.20000 |
| LogP | 3.78020 |
| InChIKey | SVYNLIRHKQCPNE-UHFFFAOYSA-N |
| SMILES | N=C(N)N1CCc2ccccc2C1.O=S(=O)(O)O |
| Storage condition | -20°C Freezer |
| Water Solubility | H2O: 20 mg/mL with heat |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 610 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,129,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 235 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 132 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 136 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 31700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NW7010000 |
| HS Code | 2933499090 |
Customs
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1) |
| Debrisoquin hemisulfate |
| Bis[3,4-dihydroisoquinolin-2(1H)-yl(imino)methanaminium] sulfate |
| debrisoquine sulfate |
| 3,4-Dihydroisoquinoline-2(1H)-carboximidamide sulfate (2:1) |
| 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide sulfate (2:1) |
| Debrisoquin sulfate |
| debrisoquine sulphate |
