CAS 32828-81-2|Picotamide

Introduction：Basic information about CAS 32828-81-2|Picotamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Picotamide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles29
8. Synonyms

Common Name	Picotamide
CAS Number	32828-81-2	Molecular Weight	376.40900
Density	1.246g/cm3	Boiling Point	668.1ºC at 760mmHg
Molecular Formula	C₂₁H₂₀N₄O₃	Melting Point	124ºC
MSDS	ChineseUSA	Flash Point	357.8ºC

Names

Name	4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide
Synonym	More Synonyms

Picotamide BiologicalActivity

Description	Picotamide is a combined inhibitor of thromboxane A2 (TxA2) synthase and receptor. Picotamide has antiplatelet activity. Picotamide promotes the reduction of microalbuminuria and the inhibition of growth of carotid plaques in diabetes. Picotamide can be used for researching acute or chronic cardiovascular diseases[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Prostaglandin Receptor
References	[1]. Celestini A, et al. A review of picotamide in the reduction of cardiovascular events in diabetic patients. Vasc Health Risk Manag. 2007;3(1):93-98.

Chemical & Physical Properties

Density	1.246g/cm3
Boiling Point	668.1ºC at 760mmHg
Melting Point	124ºC
Molecular Formula	C₂₁H₂₀N₄O₃
Molecular Weight	376.40900
Flash Point	357.8ºC
Exact Mass	376.15400
PSA	93.21000
LogP	3.12700
Index of Refraction	1.614
InChIKey	KYWCWBXGRWWINE-UHFFFAOYSA-N
SMILES	COc1ccc(C(=O)NCc2cccnc2)cc1C(=O)NCc1cccnc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ2235500

CHEMICAL NAME :: 1,3-Benzenedicarboxamide, N,N'-bis(3-pyridinylmethyl)-4-methoxy-

CAS REGISTRY NUMBER :: 32828-81-2

BEILSTEIN REFERENCE NO. :: 0499268

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H20-N4-O3

MOLECULAR WEIGHT :: 376.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2080288

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1205 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3973026

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2080288

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	CZ2235500
HS Code	2933399090

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles29

Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism.

Thromb. Haemost. 78(5) , 1385-91, (1997)

Picotamide is a dual thromboxane (Tx) A2 receptor antagonist/Tx synthase inhibitor although some observations suggest an anti-vasoconstrictor effect independent of TxA2 inhibition/antagonism. The aim ...

Determinants of fibrinogen in an Italian population suffering from claudication. Lower fibrinogen in the south compared to middle and north of Italy. The ADEP Group.

Haematologica 83(8) , 701-7, (1998)

Prospective studies have shown that high plasma levels of fibrinogen are independently associated with the risk of cardiovascular complications. In patients suffering from peripheral vascular disease ...

Thromboxane inhibition improves renal perfusion and excretory function in severe congestive heart failure.

J. Am. Coll. Cardiol. 42(1) , 133-9, (2003)

The aim of this study was to evaluate whether thromboxane inhibition can favorably affect renal perfusion and clinical conditions in patients affected by severe heart failure.The renal formation of th...

Synonyms

EINECS 251-245-7

MFCD00866792

4-methoxy-N,N'-bis-pyridin-3-ylmethyl-isophthalamide

Plactidil

picotamide

4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

G 137

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