Introduction：Basic information about CAS 189275-74-9|Ac-Trp-Glu-His-Asp-AMC, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-Trp-Glu-His-Asp-AMC |
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| CAS Number | 189275-74-9 | Molecular Weight | 784.771 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 1399.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C38H40N8O11 | Melting Point | / |
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| MSDS | / | Flash Point | 800.3±34.3 °C |
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Names
| Name | ac-wehd-amc |
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| Synonym | More Synonyms |
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Ac-Trp-Glu-His-Asp-AMC BiologicalActivity
| Description | Ac-Trp-Glu-His-Asp-AMC (Ac-Trp-Glu-His-Asp-AMC) is a potent fluorogenic substrate of caspase-1[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Apoptosis >>Caspase |
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| References | [1]. Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 1399.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C38H40N8O11 |
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| Molecular Weight | 784.771 |
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| Flash Point | 800.3±34.3 °C |
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| Exact Mass | 784.281677 |
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| PSA | 294.78000 |
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| LogP | 1.29 |
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| Appearance of Characters | powder | white |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.667 |
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| InChIKey | NONBZTYCHSGHGG-KRCBVYEFSA-N |
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| SMILES | CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CC(=O)O)C(=O)Nc1ccc2c(C)cc(=O)oc2c1 |
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| Storage condition | −20°C |
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Safety Information
Synonyms
| ac-trp-glu-his-asp-mca |
| ac-trp-glu-his-asp-7-amino-4-methylcoumarin |
| L-α-Asparagine, N-acetyl-L-tryptophyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- |
| pase-5 substrate iii,fluorogenic |
| ac-trp-glu-his-asp-amc |
| ac-wehd-mca |
| n-acetyl-trp-glu-his-asp 7-amido-4-methylcoumarin |
| N-Acetyl-L-tryptophyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine |
| pase-1 substrate x,fluorogenic |
