Introduction：Basic information about CAS 4569-86-2|ci 50206, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy)[1][2].
Related Catalog
Research Areas >>CancerSignaling Pathways >>Neuronal Signaling >>AChE
Target
Acetylcholinesterase:1.58 μM (Ki)
Butyrylcholinesterase:0.51 μM (Ki)
In Vitro
Methylene Violet 3RAX shows antitumor activity by cutting off DNA strands in tumour cell[1].Methylene Violet 3RAX (0-400 µM) significantly enhances cleavage of DNA with over 60% photocleavage activity towards DNA at 300 μM[1].
References
[1]. Si Yao, et al. Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study. RSC Advances. 2022,12, 21004-21013.
[2]. Onder S, et al. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX. Chem Biol Interact. 2019 Dec 1;314:108845.
