CAS 641-38-3|Alternariol
Introduction：Basic information about CAS 641-38-3|Alternariol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alternariol | ||
|---|---|---|---|
| CAS Number | 641-38-3 | Molecular Weight | 258.226 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 586.9±39.0 °C at 760 mmHg |
| Molecular Formula | C14H10O5 | Melting Point | 350°C (rough estimate) |
| MSDS | ChineseUSA | Flash Point | 232.3±20.6 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | alternariol |
|---|---|
| Synonym | More Synonyms |
Alternariol BiologicalActivity
| Description | Alternariol is a mycotoxin produced by Alternaria species. AOH inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes[1]. Alternariol exhibits a variety of therapeutic and biological properties such as phytotoxicity, cytotoxicity, anti-HIV, anti-cancer, and anti-microbial properties[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>TopoisomeraseResearch Areas >>Infection |
| References | [1]. Fliszár-Nyúl E, et al. Interaction of Mycotoxin Alternariol with Serum Albumin. Int J Mol Sci. 2019 May 12;20(9). pii: E2352. [2]. Grover S, et al. The Alternaria alternate Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation. Int J Mol Sci. 2017 Jul 20;18(7). pii: E1577. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 586.9±39.0 °C at 760 mmHg |
| Melting Point | 350°C (rough estimate) |
| Molecular Formula | C14H10O5 |
| Molecular Weight | 258.226 |
| Flash Point | 232.3±20.6 °C |
| Exact Mass | 258.052826 |
| PSA | 90.90000 |
| LogP | 2.93 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.731 |
| InChIKey | CEBXXEKPIIDJHL-UHFFFAOYSA-N |
| SMILES | Cc1cc(O)cc2oc(=O)c3c(O)cc(O)cc3c12 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 9-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 13-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- REFERENCE :
- EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H310-H330 |
| Precautionary Statements | P260-P264-P280-P284-P302 + P350-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Phrases | 26/27/28 |
| Safety Phrases | 28-36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | HP8757000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2914400090 |
Customs
| HS Code | 2914400090 |
|---|---|
| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
Articles28
More Articles| Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol. Toxicology 326 , 119-29, (2014) The mycotoxin alternariol (AOH), a frequent contaminant in fruit and grain, is known to induce cellular stress responses such as reactive oxygen production, DNA damage and cell cycle arrest. Cellular ... | |
| AFLP variability, toxin production, and pathogenicity of Alternaria species from Argentinean tomato fruits and puree. Int. J. Food Microbiol. 145(2-3) , 414-9, (2011) Large amounts of tomato fruits and derived products are produced in Argentina and may be contaminated by Alternaria toxins. Limited information is available on the genetic variability, toxigenicity, a... | |
| Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice. Toxicol. Lett. 214(1) , 46-52, (2012) Alternaria spp. are known to form a spectrum of secondary metabolites with alternariol (AOH), alternariol monomethyl ether (AME), altenuene (ALT) and tenuazonic acid (TA) as the major mycotoxins with ... |
Synonyms
| Alternariol |
| Alternariol from Alternaria sp. |
| 3,7,9-Trihydroxy-1-methyl-6H-benzo[c]chromen-6-one |
| 6H-Dibenzo[b,d]pyran-6-one, 3,7,9-trihydroxy-1-methyl- |
| AOH |
| 3,7,9-trihydroxy-1-methylbenzo[c]chromen-6-one |
